Antibodies against Hepatitis E virus

Anti-hepatitis E virus (HEV)

Infections with hepatitis E virus (HEV) are after hepatitis A and B the most frequent cause of hepatitis worldwide. Since the clinical symptoms of hepatitis E resemble those of other hepatitides, laboratory diagnostics play an essential role in diagnosis. Alongside PCR detection of viral RNA in blood or stool, the serological determination of antibodies of classes IgA/IgG/IgM against HEV is the most important aid for diagnosis of an HEV infection. Pathogen-specific antibodies are usually detectable when the first clinical symptoms appear or shortly afterwards. A positive IgA and/or IgM test and a significant increase in IgG in a serum pair (taken at a time interval of 8-14 days) indicate  an acute infection. IgA and IgM anti-HEV titers usually drop rapidly after infection, while the IgG HEV titer persists for over 10 years.

EUROIMMUN offers the following ELISAs for the detection of HEV-specific antibodies:


ProductOrder number
Anti-Hepatitis E Virus (HEV) ELISA (IgA / IgG / IgM / Polyvalent)EI 2525 A / G / M / P

Test advantages at a glance:

  • Complete range of CE-labelled ELISAs for separate or parallel determination of IgA, IgG and IgM antibodies against HEV
  • Highest sensitivity and specificity for antibody detection through use of carefully selected recombinant target antigens of HEV genotypes 1 and 3 as the antigenic substrate
  • Quantification in international units (IU/ml) – the only commercial anti-HEV ELISA (IgG) to offer this
  • First-rate linearity with respect to the WHO standard
  • Ideal for differential diagnostics, blood donor screening (in combination with PCR detection of HEV RNA) and epidemiology
  • Fully automatable