Tick-borne infections

Clinical information

Ticks can transmit different viral, bacterial and parasitic infectious agents to a person during blood feeding. Alongside Borrelia, which causes Lyme borreliosis, the most frequent tick-borne disease in the northern hemisphere, the range of pathogens include TBE virus, Crimean-Congo fever virus, Anaplasma, Rickettsia, Babesia, Ehrlichia and Coxiella. Depending on the pathogen, tick-borne infections may lead to various clinical symptoms, with involvement of, for example, the skin, joints, muscles, inner organs and central nervous system. Disease courses range from asymptomatic or subclinical to severe and life-threatening. Since there are only vaccines to some of the tick-borne pathogens, exposition prophylaxis is the most effective protection measure. 

Diagnostics

Laboratory diagnostics of tick-borne infections are based on direct and indirect detection methods. Direct procedures include e.g. blood smears, pathogen cultures or PCR-based tests, while indirect detection is mainly based on the detection of specific antibodies against the respective pathogen in patient serum, plasma or CSF. Detection of antibodies is the most important laboratory diagnostic method in cases where it is difficult to obtain suitable sample materials for direct detection, or the amount of pathogen in the sample is too low. EUROIMMUN offers a broad spectrum of serological test systems for the detection of antibodies in suspected tick-borne infections, e.g. ELISA, ChLIA, immunofluorescence tests (IFT) and immunoblots.

Selected Products

Method
Parameter
Substrate
Species
IIFT
antibodies against Borrelia afzelii/B. burgdorferi/B. garinii/VlsE
IgG positive control
IIFT
antibodies against Borrelia afzelii/B. burgdorferi/B. garinii/OspC
IgM positive control
IIFT
Borrelia afzelii/B. burgdorferi/B. garinii
negative control
EUROLINE
positive control serum: IgG, human, 50x concentrated
for Borrelia
EUROLINE
positive control serum: IgM, human, 50x concentrated
for Borrelia
WESTERNBLOT
antibodies against Borrelia afzelii
IgG positive control
(Westernblot/EUROLINE-WB)
WESTERNBLOT
antibodies against Borrelia afzelii
IgM positive control
(Westernblot/EUROLINE-WB)
EUROLINE
EUROLINE Borrelia-RN-AT
(p18, p19, p20, p21, p58,
OspC (p25), p39, p83, LBb, LBa,
VlsE Bg, VlsE Bb, VlsE Ba separately)
EUROLINE
EUROLINE
EUROLINE Borrelia-RN-AT
(OspC Bg native, OspC Bb native,
OspC Ba native, p39, VlsE Bb separately)
EUROLINE
WESTERNBLOT
Borrelia afzelii
Westernblot
whole antigen, SDS extract of
Borrelia afzelii
WESTERNBLOT
EUROLINE-WB
Borrelia
Westernblot
whole antigen, SDS extract of
Borrelia afzelii plus VlsE
EUROLINE
EUROLINE Borrelia-RN-AT-adv
(OspC-adv Bsp, OspC-adv Bg, OspC-adv
Bb, OspC-adv Ba, p39, VlsE Bb separately)
EUROLINE
WESTERNBLOT
antibodies against Borrelia burgdorferi
IgG positive control
WESTERNBLOT
antibodies against Borrelia burgdorferi
IgM positive control
WESTERNBLOT
Borrelia burgdorferi
Westernblot
whole antigen, SDS extract of
Borrelia burgdorferi sensu stricto
ELISA
Borrelia
incl. IgG/RF absorbent
antigen-coated
microplate wells
IIFT
Borrelia
burgdorferi
(CH)
bacterial
smear
verification BIOCHIP
(2 BIOCHIPs per field)
Borrelia
burgdorferi
(CH)
ChLIA
Borrelia
ChLIA
Borrelia
ChLIA
Control set
Borrelia
ELISA
Borrelia burgdorferi
VlsE
antigen-coated
microplate wells
ELISA
Borrelia
plus VlsE
antigen-coated
microplate wells
ELISA
Lyme ELISA
antigen-coated
microplate wells
ELISA
Borrelia Select: recombinant
antigens with VlsE
antigen-coated
microplate wells
ELISA
Borrelia Select: recombinant
antigens with OspC advanced
antigen-coated
microplate wells
ELISA
CSQ pair of controls
anti-Borrelia (IgG)
ELISA
CSQ pair of controls
anti-Borrelia (IgM)
ELISA
Borrelia PLUS VlsE
antibody determination in CSF
antigen-coated
microplate wells
ELISA
Borrelia
antibody determination in CSF
antigen-coated
microplate wells
WESTERNBLOT
Borrelia Burgdorferi US
EUROLINE-WB
Westernblot
whole antigen, SDS extract of
Borrelia burgdorferi plus flagellin
WESTERNBLOT
antibodies against Borrelia garinii
IgG positive control
WESTERNBLOT
antibodies against Borrelia garinii
IgM positive control
WESTERNBLOT
Borrelia garinii
Westernblot
whole antigen, SDS extract
of Borrelia garinii
WESTERNBLOT
Borrelia garinii
Westernblot
whole antigen, SDS extract of
Borrelia garinii
IIFT
EUROPLUS
Borrelia afzelii
Borrelia burgdorferi (USA)
OspC antigen
VlsE antigen
4 BIOCHIPs per field:
bacterial smear
bacterial smear
OspC BIOCHIPs
VlsE BIOCHIPs

B. afzelii
B. burgd. (USA)
B. burgdorferi
recombinant
IIFT
Borrelia afzelii
Borrelia burgdorferi (CH)
Borrelia burgdorferi (USA)
Borrelia garinii
bacterial
smears
(4 BIOCHIPs per field)
B. afzelii
B. burgdorferi (CH)
B. burgdorferi (USA)
B. garinii
ELISA
Coxiella burnetii phase 1
antigen-coated
microplate wells
ELISA
Coxiella burnetii phase 2
antigen-coated
microplate wells
IIFT
antibodies against TBE virus (TBEV)
IgG positive control
IIFT
antibodies against TBE virus (TBEV)
IgM positive control
IIFT
TBE virus (TBEV)
negative control
ELISA
TBE virus
antigen-coated
microplate wells
ELISA
TBE virus
incl. IgG/RF absorbent
antigen-coated
microplate wells
IIFT
TBE virus (TBEV)
infected and non-
infected cells
(2 BIOCHIPs per field)
EU 14
IIFT
antibodies against Flaviviruses
IgG positive control
IIFT
Flaviviruses
negative control
ELISA
TBE virus
avidity determination
antigen-coated
microplate wells
IIFT
Flavivirus Mosaic 1
TBE virus (TBEV)
West Nile virus (WNV)
Japanese encephalitis virus (JEV)
Yellow fever virus (YFV)
4 BIOCHIPs per field:
infected cells
infected cells
infected cells
infected cells

EU 14
EU 14
EU 14
EU 14
IIFT
Flavivirus Profile 2
upper row:
TBE virus (TBEV)
West Nile virus (WNV)
Japanese encephalitis virus (JEV)
Yellow fever virus (YFV)
bottom row:
Dengue virus
types 1 - 4 (DENV)


infected cells
infected cells
infected cells
infected cells

infected cells


EU 14
EU 14
EU 14
EU 14

EU 14
IIFT
Flavivirus Mosaic 3
TBE virus (TBEV)
West Nile virus (WNV)
Japanese encephalitis virus (JEV)
Yellow fever virus (YFV)
Dengue virus types 1 - 4 (DENV)
9 BIOCHIPs per field:
infected cells
infected cells
infected cells
infected cells
infected cells
non-infected cells

EU 14
EU 14
EU 14
EU 14
EU 14
EU 14
ELISA
CSQ pair of controls
anti-TBE virus Vienna (IgG)
ELISA
TBE virus
Vienna
antigen-coated
microplate wells
ELISA
CSQ pair of controls
anti-TBE virus (IgG)
ELISA
CSQ pair of controls
anti-TBE virus (IgM)
ELISA
TBE virus
antibody determination in CSF
antigen-coated
microplate wells
IIFT
antibodies against Crimean Congo fever virus (CCHFV)
IgG positive control
IIFT
antibodies against Crimean Congo fever virus (CCHFV)
IgM positive control
IIFT
Crimean Congo fever virus (CCHFV)
negative control
IIFT
Crimean Congo fever virus Mosaic 2
CCHFV-GPC
CCHFV-N
3 BIOCHIPs per field:
transfected cells
transfected cells
control transfection

EU 90
EU 90
EU 90
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