Thyroid-specific autoantibodies

EUROPLUS thyroid gland (monkey) and thyroglobulin antigen

Thyroid gland, unfixed and thyroglobulin BIOCHIP: antibodies against thyroid microsomes and thyroglobulin
  • Detection of antibodies against thyroid gland antigens.
  • Indications: Graves' disease, Hashimoto's autoimmune thyroiditis.
  • Initial dilution 1 : 10; conjugate class anti-human IgG, FITC-labelled.
  • Using unfixed thyroid tissue, two important thyroid-specific antibodies can be found: Autoantibodies against thyroid microsomes (MAb) give a granular staining in the cytoplasm of the follicle epithelium (target antigen: thyroid peroxidase, TPO). Autoantibodies against thyroglobulin (TAb) react with the colloid of all follicles of the thyroid tissue and cause a reticular fluorescence pattern.
  • With the thyroglobulin-coated BIOCHIP, autoantibodies against thyroglobulin (TG) can be confirmed monospecifically in one and the same test procedure.
  • This BIOCHIP Mosaic can be supplemented as required with further substrates, e.g. rat kidney, to achieve a differentiation of antibodies against thyroid microsomes from mitochondrial antibodies (AMA). For a serological diagnosis of autoimmune polyendocrinopathies, BIOCHIPs with frozen sections of pancreas, adrenal gland, ovary, testis and stomach can be added.

ProductOrder number
EUROPLUS thyroid gland (monkey) and thyroglobulin antigenFA 1010-3

Anti-thyroglobulin, anti-thyroid peroxidase, anti-TSH receptor

Incubated anti-thyroid antigen ELISAs
  • Monospecific determination of antibodies against thyroglobulin (TG), thyroid peroxidase (TPO), and thyrotropin receptor (TSH-R).
  • Indications: Graves' disease, Hashimoto's autoimmune thyroiditis.
  • Serum dilution 1 : 201 (exception: anti-TSH-R); conjugate class anti-human IgG, POD-labelled (anti-TSH-R: avidin-labelled).
  • 3-point calibration (exception: TSH-R, 5-point calibration).
  • The quantification is carried out according to international reference preparations (anti-TG: NIBSC 65/93; anti-TPO: NIBSC 66/387; anti-TSH-R: NIBSC 90/672).
  • Thyroglobulin/TSH-R: native antigen; thyroid peroxidase: recombinant antigen.

ProductOrder number
Anti-Thyroid Peroxidase ELISAEA 1012 G
Anti-Thyroglobulin ELISAEA 1013 G
Anti-TSH Receptor ELISAEA 1015 G
Anti-TSH Receptor Fast ELISAEA 1015-1 G

Thyroid-specific autoantibodies

RIA for the thyroid diagnostic
  • Monospecific detection of autoantibodies against thyroglobulin (TG), thyroid peroxidase (TPO) and thyrotropin receptor (TSH-R).
  • Indications: Graves' disease, Hashimoto's thyroiditis.
  • Serum dilutions: 1:51 for anti-TG and anti-TPO (magnetic), 1:21 for anti-TPO (precipitation), undiluted for all remaining test kits.
  • 5-point to 6-point calibration (quantitative).

ProductOrder number
Anti-TPO RIARA 1012
Anti-TG RIARA 1013
Anti-TSH Receptor RIARA 1015