Infertility

Clinical information

Unwanted childlessness can be due to immune-mediated destruction of reproductive tissue. The antibodies are directed e.g. against spermatozoa and steroid-producing cells in the ovaries and testes. The so-called autoimmune infertility often occurs in conjunction with other autoimmune diseases.

In 20% of immunological fertility disorders, anti-spermatozoa antibodies are detected in both male and female patients (autoantibodies/alloantibodies). The antibodies mainly affect the spermatozoa’s motility through surface binding and agglutination processes.

Antibodies against ovarian antigens are detected in women with primary ovarian insufficiency and after repeated in vitro fertilisation.  The autoantibodies are directed against different ovarian structures and inhibit the maturation of the ovum and its interaction with the spermatozoa. The target antigens are steroid-producing enzymes, especially in the cells of the theca interna, and the zona pellucida.

Diagnostics

Using IIFT: The Infertility Mosaic -7 detects serum antibodies against spermatozoa and Leydig cells as well as against ovarian, placental and uterus antigen by means of indirect immunofluorescence. This combination of relevant reproductive tissues and cells allows detection of possible autoimmune-associated fertility disorders of both partners in one comprehensive test.

Selected Products

Method
Parameter
Substrate
Species/ Antigen
IIFT
ovarian antigens
ovary
monkey
IIFT
Infertility Mosaic 7
ovarian antigens
Leydig cells
placental antigens
spermatozoa
uterine antigens
5 BIOCHIPs per field:
ovary
testis
placenta
smear
uterus

monkey
monkey
monkey
human
monkey
IIFT
antibodies against ovary: theca cells
(ovary ab control)
IIFT
Leydig cells
testis
monkey
IIFT
antibodies against testis: Leydig cells
(testis ab control)
IIFT
antibodies against spermatozoa
IIFT
spermatozoa
smear
human
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