HLA-DRB1 Shared Epitope

EUROArray HLA-DRB1 Shared Epitope

The marker "shared epitope" is the most important genetic risk factor for the development of rheumatoid arthritis. It comprises characteristic peptide sequences at position 70-74 of the β1 chain of the human leukocyte antigen DR (HLA-DR), which are encoded by various alleles of the HLA-DRB1 gene. Analysis of shared-epitope alleles enables genetic risk assessment with respect to the presence or development of rheumatoid arthritis, and prognosis of the expected disease course: The peptide sequences QKRAA, QRRAA, RRRAA and DKRAA are associated with high risk of developing rheumatoid arthritis and a severe disease course (high-risk alleles). The peptide sequences DRRAA, QARAA and DERAA, in contrast, are connected with a low disease risk and in some studies have even been described as protective.

The EUROArray HLA-DRB1 Shared Epitope allows detection and differentiation of alleles for all relevant shared-epitope peptide sequences in one test. Moreover, through the integrated parallel detection of non-shared epitope alleles, the assay allows differentiation between homozygous and heterozygous carriers. It thus provides improved risk assessment.

Compared to other molecular biological procedures for the detection of shared-epitope alleles, the EUROArray HLA-DRB1 Shared Epitope is extremely simple to perform and does not require in-depth molecular biology knowledge. Data analysis, data interpretation and electronic archiving are fully automated with the EUROArrayScan software.

ProductOrder number
EUROArray HLA-DRB1 Shared EpitopeMN 5150