ANA (anti-dsDNA, anti-nucleosomes)

Anti-dsDNA-NcX

Incubated Anti-dsDNA-NcX ELISA
  • Monospecific detection of antibodies against dsDNA.
  • Indication: systemic lupus erythematosus.
  • Serum dilution 1: 201, conjugate class anti-human IgG, POD-labelled.
  • Antibodies against dsDNA can be determined quantitatively in IU/ml.
  • 3-point calibration, quantitative.
  • Antigen: double-stranded DNA, complexed with nucleosomes (NcX).
  • Due to good sensitivity and specificity, the Anti-dsDNA-NcX ELISA stands out by high diagnostic efficiency. High concentrations of autoantibodies against dsDNA in the ELISA are considered to be a reliable marker for the diagnosis or prognosis of SLE. Individual changes in the dsDNA antibody concentration correlate with the activity of the disease and can be used for monitoring the development of the disease in SLE patients. Under immunosuppressive therapy or in clinical remission dsDNA antibodies often cannot be detected with ELISA anymore.
ProductOrder number
Anti-dsDNA-NcX ELISA (IgG)EA 1572 G

EUROLINE: ANA Profile 3

Incubated EUROLINE ANA Profile 3
  • Differentiation of antibodies against cell nuclei (ANA).
  • Indications: Sharp syndrome (MCTD), systemic lupus erythematosus, Sjögren’s syndrome, systemic sclerosis, poly/dermatomyositis, PBC.
  • Serum dilution 1 : 101; conjugate class anti-human IgG, AP-labelled.
  • With the EUROLINE ANA Profile 3, fifteen autoantibodies can be determined: antibodies against nRNP/Sm, Sm, SS-A, Ro-52, SS-B, Scl-70, PM-Scl, Jo-1, centromere protein B, PCNA, dsDNA, nucleosomes, histones, ribosomal P-proteins, AMA M2.
  • Antibodies against SS-A are characteristic markers for SLE and Sjögren’s syndrome. In contrast, antibodies against Ro-52 also occur in patients with other autoimmune diseases.
  • Native antigens, purified by affinity chromatography (exception: centromere protein B, PM-Scl, Ro-52, PCNA).
  • Test strips can be automatically incubated and evaluated using the systems EUROBlotOne, EUROBlotMaster and EUROLineScan.
ProductOrder number
EUROLINE ANA Profile 3 DL 1590-3 G

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EUROASSAY: Anti-ENA ProfilePlus

Incubated Anti-ENA ProfilPlus EUROASSAY
  • Differentiation of anti-nuclear antibodies (ANA).
  • Indications: rheumatic diseases.
  • Serum dilution 1 : 101; conjugate class anti-human IgG, AP-labelled.
  • 6 relevant anti-nuclear antibodies against "extractable nuclear antigens" (ENA) can be detected simultaneously and monospecifically: antibodies against nRNP/Sm, Sm, SS-A, SS-B, Scl-70, Jo-1.
  • Native antigens, purified by affinity chromatography.
  • On request EUROASSAY can be produced with special antigen combinations, for example, with dsDNA, histones, nucleosomes, PM-Scl, nRNP/Sm, Sm, SS-A, Ro-52, SS-B, Scl-70, Jo-1, ribosomal P proteins, centromere protein B, M2, M4, M9, SLA/LP, LC-1, LKM-1.

ProductOrder number
Anti-ENA ProfilePlus EUROASSAY  DA 1590-1 G