Calcitonin

Calcitonin

Clinical significance

Calcitonin is a peptide hormone that is involved in regulating the calcium level and is produced in the parafollicular cells of the thyroid gland (C cells). Its production is stimulated by a raised calcium level or gastrointestinal hormones, e.g. pentagastrin. Calcitonin inhibits osteoclast activity and decreases the calcium concentration in the blood. Low Calcitonin levels are associated with osteopenia, a preliminary stage of osteoporosis, which is why calcitonin is among the substances given in osteoporosis therapy.

Diagnostics

Calcitonin serodiagnostics is generally indicated for clarification of scintigraphically cold thyroid nodules, therapy-resistant diarrhoea and unexplainable increase in the CEA value (carcinoembryonic antigen). Furthermore, determination of the calcitonin level in blood is required in paraneoplastic or reactive hypercalcaemia and for monitoring and relapse monitoring following surgical removal of C-cell carcinoma.

ProductOrder number
Calcitonin ELISAEQ 6431

Radioimmunoassays (RIA/IRMA): Thyroid-specific autoantibodies, antigens and hormones

Radioimmunoassays (RIA) for the diagnosis of thyroid diseases
  • Monospecific determination of autoantibodies against thyroglobulin (TG), thyroid peroxidase (TPO) and thyrotropin receptors (TSH-R).
  • Specific determination of the thyroid antigen thyrotropin and the hormones free triiodothyronine, (FT3), free thyroxine (FT4), thyrotropin (TSH), calcitonin.
  • Indication: Hashimoto's thyroiditis, Graves' disease, medullary thyroid carcinoma (MTC), thyroidal C-cell hyperplasia, therapy monitoring in hyperthyrosis and hypothyrosis.
  • Serum dilutions: 1:50 in anti-TG and anti-TPO (magnetic), 1:20 in anti-TG and anti-TPO (precipitation), undiluted in all other test kits.
  • 5-point to 8-point calibration (quantitative).
ProductOrder number
Calcitonin RD 1019