Reverse triiodothyronine

Clinical

The biologically active metabolite reverse triiodothyronine (rT3) is created during impaired conversion of tetraiodothyronine (T4) to triiodothyronine (T3).

Diagnostics

Low T3 syndrome (euthyroid sick syndrome, non-thyroidal illness) is characterised by a disturbed homeostasis of thyroid hormones. This results in an accumulation of the inactive metabolite rT3, a normal to low TSH level, a low FT3 level and, with a long disease duration, a low FT4 level. The determination of rT3 can be useful to differentiate between patients with central hypothyroidism and patients with low T3 syndrome.

Selected Products

Method
Parameter
Substrate
ELISA
reverse triiodothyronine (RT3)
antibody-coated
microplate wells
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