Calcitonin

Clinical information

Calcitonin is a peptide hormone that is involved in regulating the calcium level and is produced in the parafollicular cells of the thyroid gland (C cells). Its production is stimulated by a raised calcium level or gastrointestinal hormones, e.g. pentagastrin. Calcitonin inhibits osteoclast activity and decreases the calcium concentration in the blood. Low calcitonin levels are associated with osteopenia, a preliminary stage of osteoporosis, which is why calcitonin is among the substances given in osteoporosis therapy.

Diagnostics

Calcitonin serodiagnostics is generally indicated for clarification of scintigraphically cold thyroid nodules, therapy-resistant diarrhoea and unexplainable increase in the CEA value (carcinoembryonic antigen). Furthermore, determination of the calcitonin level in blood is required in paraneoplastic or reactive hypercalcaemia and for monitoring and relapse monitoring following surgical removal of C-cell carcinoma.

Selected Products

Method
Parameter
Substrate
Species
RIA
calcitonin
coated tubes (CT); IRMA
antibody-coated
tubes
calcitonin,
human
ELISA
calcitonin
antibody-coated
microplate wells
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