Hu, Yo, Ri, CV2, Ma, amphiphysin, PCA-2, Tr, SOX1, titin, recoverin

Neurology Mosaic 1

Cerebellum (left) and intestine (right): anti-Hu (ANNA-1) (top), anti-Ri (ANNA-2) (middle), anti-Yo (PCA-1) (bottom)
  • Screening test for the detection of antibodies against neuronal antigens.
  • Indications: neurological diseases.
  • Initial dilution 1 : 10; conjugate class anti-human IgG, FITC-labelled.
  • Substrates: cerebellum (monkey), nerves (monkey), intestine (monkey)
  • Primate cerebellum and primate nerves are the standard substrates for the determination of various neuronal antibodies. The parallel use of primate intestine permits the reliable differentiation from other autoantibodies (e.g. ANA) and makes it possible to distinguish between anti-Ri and anti-Hu.
  • Antibodies against Yo stain exclusively the cytoplasm of the Purkinje cells in the cerebellum. Clinical significance: paraneoplastic neurological syndromes (PNS), indication of a malignoma.
  • In the case of antibodies against Hu and Ri all neurone nuclei in the grey matter show a granular fluorescence. Hu antibodies react in the intestine with cell nuclei of the plexus myentericus, whereas Ri antibodies do not. Clinical significance: paraneoplastic neurological syndromes (PNS), indication of a malignoma.
ProductOrder number
Neurology Mosaic 1 FA 1111-1

EUROLINE: Paraneoplastic Neurological Syndromes 12 Ag

Incubated EUROLINE Neuronal Antigens Profile 12 Ag
  • Differentiation of antibodies against neuronal antigens.
  • Indication: paraneoplastic neurologic syndromes (PNS).
  • Serum dilution 1 : 101; conjugate class anti-human IgG, AP-labelled.
  • With the EUROLINE Neuronal Antigen Profile 7, twelve autoantibodies can be determined: antibodies against amphiphysin, CV2 (CRMP5), PNMA2 (Ma2/Ta), Ri, Yo, Hu, recoverin, SOX1, Titin, Zic4, GAD65 and Tr (DNER).
  • Test strips can be automatically incubated and evaluated using the systems EUROBlotMaster and EUROLineScan or EUROBlotOne.
ProductOrder number
EUROLINE Paraneoplastic Neurological Syndromes 12 Ag
(separate: amphiphysin, CV2 (CRMP5), PNMA2 (Ma-2/Ta), Ri, Yo, Hu, recoverin, SOX1, Titin, Zic4, GAD65, Tr (DNER))
DL 1111-1601-7 G