Clinical information
Connective tissue diseases (CTD) are rheumatic diseases and include, for example, systemic lupus erythematosus, systemic sclerosis, Sjögren's syndrome, myositis syndromes and Sharp syndrome.
Autoantibodies against cellular components, commonly called anti-nuclear antibodies (ANA), are important serological markers for CTD. Target antigens include nucleic acids, cell nuclear proteins and ribonuclear proteins as well as components of the cytoplasm. The frequency (prevalence) of ANA in systemic rheumatic diseases varies between 20 % and 100 %. The different target antigens are associated with different rheumatic diseases. Multi-tier ANA diagnostics is therefore indispensable for differentiation of the specific antibodies in order to distinguish individual rheumatic diseases as well as to differentiate them from other (autoimmune) diseases.
Diagnostics
The gold standard for the determination of ANA is the indirect immunofluorescence test (IIFT) with human epithelial cells (HEp-2), which is known for its high sensitivity. In the microscopic evaluation it is possible to establish precisely how an indicator dye (generally fluorescein) is distributed in the cells. Depending on the location of the individual autoantigens, a typical fluorescence pattern for every type of autoantibody bound will appear.
The revised international consensus on a standardised nomenclature of HEp-2 cell patterns in indirect immunofluorescence (ICAP, www.anapatterns.org) defines 15 nuclear, 9 cytoplasmic and 5 mitotic patterns which are relevant for the diagnostics of various autoimmune diseases.
The EUROIMMUN BIOCHIP technology allows to combine HEp-2 cell substrates with organ sections (liver), which supports the identification and differentiation of certain patterns. Users can choose between HEp-2 cells and HEp-20-10 cells. The latter contain a far greater number of cells in mitosis, which facilitates pattern interpretation.
For confirmation of IIFT results ICAP recommends to subsequently perform specific antibody tests (e.g. ELISA, line blot, ChLIA). However, the exclusive use of these monospecific test methods is insufficient for the determination of ANA, as not all relevant antigens are available yet in purified form. Thus, the corresponding ANA can only be detected by IIFT.
Methods
| Technology | Parameter | Substrate | Species | Calibration | Ig Class | Format | Order No. |
|---|---|---|---|---|---|---|---|
| IIFT | cell nuclei (ANA) |
HEp-2 cells (1 BIOCHIP per field) |
human | IgG IgG IgG IgG |
10 x 50 120 x 10 20 x 05 20 x 10 |
FA 1520-1050-R FA 1520-12010-R FA 1520-2005-R FA 1520-2010-R |
|
| IIFT | cell nuclei (ANA) |
HEp-20-10 cells (1 BIOCHIP per field) |
human | IgG IgG IgG IgG |
10 x 50 120 x 10 20 x 05 20 x 10 |
FA 1522-1050-R FA 1522-12010-R FA 1522-2005-R FA 1522-2010-R |
|
| ELISA | Anti-PM-Scl-ELISA (IgG) |
antigen-coated microplate wells |
recombinant, expression in E. coli |
2/20/200 RU/ml | IgG |
96 x 01 |
EA 1584-9601 G |
| ELISA | Anti-nRNP/Sm ELISA (IgG) |
antigen-coated microplate wells |
native, U1-nRNP, incl. 70K, A, C, B, B', D, E, F, G, calf thymus |
2/20/200 RU/ml | IgG |
96 x 01 |
EA 1591-9601 G |
| ELISA | Anti-Jo-1 ELISA (IgG) |
antigen-coated microplate wells |
native, histidyl-tRNA synthetase, calf thymus |
2/20/200 RU/ml | IgG |
96 x 01 |
EA 1661-9601 G |
| ELISA |
Anti-cN-1A ELISA (IgG) Mup44, NT5C1A |
antigen-coated microplate wells |
recombinant, expression in E. coli | semi-quantitative | IgG |
48 x 01 |
EA 1675-4801 G |
| EUROLINE |
EUROLINE Myositis Antigens Profile (IgG) (Mi-2, Ku, PM-Scl, Jo-1, PL-7, PL-12, Ro-52 separately) |
EUROLINE | IgG |
16 x 01 |
DL 1530-1601 G | ||
| EUROLINE |
EUROLINE Myositis Antigens Profile 3 (IgG) (Mi-2, Ku, PM-Scl100, PM-Scl75, Jo-1, SRP, PL-7, PL-12, EJ, OJ, Ro-52 separately) |
EUROLINE | IgG IgG IgG |
16 x 01 50 x 01 64 x 01 |
DL 1530-1601-3 G DL 1530-5001-3 G DL 1530-6401-3 G |
||
| EUROLINE |
EUROLINE Autoimmune Inflammatory Myopathies 16 Ag (IgG) (Mi-2 alpha, Mi-2 beta, TIF1g, MDA5, NXP2, SAE1, Ku, PM-Scl100, PM-Scl75, Jo-1, SRP, PL-7, PL-12, EJ, OJ, Ro-52 separately) |
EUROLINE | IgG IgG IgG |
16 x 01 50 x 01 64 x 01 |
DL 1530-1601-4 G DL 1530-5001-4 G DL 1530-6401-4 G |
||
| EUROLINE |
EUROLINE Autoimmune Inflammatory Myopathies 16 Ag et cN-1A (IgG) (Mi-2 alpha, Mi-2 beta, TIF1g, MDA5, NXP2, SAE1, Ku, PM-Scl100, PM-Scl75, Jo-1, SRP, PL-7, PL-12, EJ, OJ, Ro-52, cN-1A separately) |
EUROLINE | IgG IgG IgG |
16 x 01 50 x 01 64 x 01 |
DL 1530-1601-7 G DL 1530-5001-7 G DL 1530-6401-7 G |
||
| EUROLINE |
EUROLINE Autoimmune Inflammatory Myopathies 20 Ag (IgG) ( Mi-2 alpha, Mi-2 beta, TIF1g, MDA5, NXP2, SAE1, Ku, PM-Scl100, PM-Scl75, Jo-1, SRP, PL-7, PL-12, EJ, OJ, Ro-52, cN-1A, Ha, Ks, Zo) |
EUROLINE | IgG IgG IgG |
16 x 01 50 x 01 64 x 01 |
DL 1530-1601-9 G DL 1530-5001-9 G DL 1530-6401-9 G |
||
| ChLIA | IDS Jo-1 | antigenic coated magnetic particles | Jo-1 |
quantitative |
50 x 01 |
IS-AI11091 | |
| ChLIA | IDS SS-A/Ro 52 kDa | antigenic coated magnetic particles | SS-A/Ro 52 kDa |
quantitative |
50 x 01 |
IS-AI11031 | |
| ChLIA | CRP | immunoturbidimetric assay |
quantitative |
01 x 190 |
CPTXL-H00/IDS1 | ||
| ELISA |
Anti-ssDNA ELISA (IgG) single-stranded DNA |
antigen-coated microplate wells |
heat-denatured ssDNA | 2/20/200 RU/ml | IgG |
96 x 01 |
EA 1576-9601 G |
| ELISA |
Anti-ENA ProfilePlus 1 ELISA (IgG) (nRNP/Sm, Sm, SS-A, SS-B, Scl-70, Jo-1 separately) |
antigen-coated microplate wells |
see individual ELISA | semi-quantitative | IgG |
12 x 08 |
EA 1590-1208-1 G |
| ELISA |
Anti-ENA PoolPlus ELISA (IgG) (antigen mixture: nRNP/Sm, Sm, SS-A, SS-B, Scl-70, Jo-1) |
antigen-coated microplate wells |
see individual ELISA | semi-quantitative | IgG |
96 x 01 |
EA 1590-9601-7 G |
| ELISA |
Anti-SS-A ELISA (IgG) Ro |
antigen-coated microplate wells |
native, SS-A-specific proteins (60 kDa), calf thymus |
2/20/200 RU/ml | IgG |
96 x 01 |
EA 1595-9601 G |
| ELISA |
Anti-SS-B ELISA (IgG) La |
antigen-coated microplate wells |
native, SS-B-specific protein (48 kDa), calf thymus |
2/20/200 RU/ml | IgG |
96 x 01 |
EA 1597-9601 G |
| ELISA | Anti-Scl-70 ELISA (IgG) |
antigen-coated microplate wells |
native, DNA topoisomerase I, calf thymus |
2/20/200 RU/ml | IgG |
96 x 01 |
EA 1599-9601 G |
| ELISA | Anti-DFS70 ELISA (IgG) |
antigen-coated microplate wells |
DFS70 recombinant |
semi-quantitative | IgG |
96 x 01 |
EA 159z-9601 G |
| ELISA | Anti-Centromeres ELISA (IgG) |
antigen-coated microplate wells |
recombinant centromere protein B, expression with baculovirus vector in insect cells |
2/20/200 RU/ml | IgG |
96 x 01 |
EA 1611-9601 G |
| EUROLINE |
positive control serum: IgG, human, 100x concentrated for DL 1530-X G |
IgG |
05 x 07 |
CL 1530-0507 G | |||
| EUROLINE |
positive control serum: IgG, human, 100x concentrated for DL 1532 G |
IgG |
05 x 07 |
CL 1532-0507 G | |||
| EUROLINE |
positive control serum: IgG, human, 100x concentrated for DL 1590-X G |
IgG |
05 x 07 |
CL 1590-0507 G | |||
| EUROLINE |
positive control serum: IgG, human, 100x concentrated for DL 1590-35 G |
IgG |
05 x 07 |
CL 1590-0507-35 G | |||
| EUROLINE |
positive control serum: IgG, human, 100x concentrated for DL 159z-X G |
IgG |
05 x 07 |
CL 159z-0507 G | |||
| EUROLINE |
EUROLINE Systemic sclerosis (Nucleoli) profile (IgG) (Scl-70, CENP A, CENP B, RP11, RP155, fibrillarin, NOR90, Th/To, PM-Scl100, PM-Scl75, Ku, PDGFR, Ro-52 separately) |
EUROLINE | IgG IgG IgG |
16 x 01 50 x 01 64 x 01 |
DL 1532-1601 G DL 1532-5001 G DL 1532-6401 G |
||
| EUROLINE |
EUROLINE Systemic Sclerosis Profile 2 (IgG) (Scl-70, CenpA, Cenp B, RP11, RP155, Fibrillarin, NOR90, Th/To, PM-Scl100, PM-Scl75, Ku, NVL und Ro-52) |
EUROLINE | IgG IgG IgG |
16 x 01 50 x 01 64 x 01 |
DL 1532-1601-2 G DL 1532-5001-2 G DL 1532-6401-2 G |
||
| EUROLINE |
EUROLINE Anti-ENA ProfilePlus 1 (IgG) (nRNP/Sm, Sm, SS-A, Ro-52, SS-B, Scl-70, Jo-1 separately) |
EUROLINE | IgG IgG |
16 x 01 64 x 01 |
DL 1590-1601-1 G DL 1590-6401-1 G |
||
| EUROLINE |
EUROLINE Anti-ENA ProfilePlus 2 (IgG) (nRNP/Sm, Sm, SS-A, Ro-52, SS-B, Scl-70, Jo-1, ribosomal P-proteins separately) |
EUROLINE | IgG IgG |
16 x 01 64 x 01 |
DL 1590-1601-2 G DL 1590-6401-2 G |
||
| EUROLINE | EUROLINE Anti-dsDNA, -Nucleosomes, -Histones, -DFS70 (IgG) | EUROLINE | IgG IgG |
16 x 01 50 x 01 |
DL 1590-1601-32 G DL 1590-5001-32 G |
||
| EUROLINE |
EUROLINE Cytoplasm profile (IgG) (AMA M2, M2-3E, ribosomal P-proteins, Jo-1 SRP, PL-7, PL-12, EJ, OJ, Ro-52 separately) |
EUROLINE | IgG IgG IgG |
16 x 01 50 x 01 64 x 01 |
DL 1590-1601-35 G DL 1590-5001-35 G DL 1590-6401-35 G |
||
| EUROLINE |
EUROLINE Cytoplasm profile 13 Ag (IgG) (CAMA-M2, M2-3E, ribosomal P-Proteins, Jo-1, SRP, PL-7, PL-12, EJ, OJ, Ro-52, Ha, Ks, Zo separately) |
EUROLINE | IgG IgG IgG |
16 x 01 50 x 01 64 x 01 |
DL 1590-1601-37 G DL 1590-5001-37 G DL 1590-6401-37 G |
||
| EUROLINE | EUROLINE Anti-DFS70 (IgG) | EUROLINE | IgG IgG |
16 x 01 50 x 01 |
DL 159z-1601 G DL 159z-5001 G |
||
| EUROASSAY |
EUROASSAY Anti-ENA ProfilePlus (IgG) (nRNP/Sm, Sm, SS-A, SS-B, Scl-70, Jo-1 separately) |
EUROASSAY strip with antigens |
IgG IgG |
DA 1590-1003-1 G DA 1590-1005-1 G |
|||
| ChLIA | IDS Scl-70 | antigenic coated magnetic particles | Scl-70 |
quantitative |
50 x 01 |
IS-AI11081 | |
| ChLIA | IDS Centromere B | antigenic coated magnetic particles | Centromere B |
quantitative |
50 x 01 |
IS-AI11101 | |
| IIFT |
antibodies against cell nuclei (ANA control), homogeneous pattern |
IgG |
05 x 02 |
CA 1570-0502 | |||
| IIFT |
antibodies against dsDNA (dsDNA ab control) |
IgG |
05 x 02 |
CA 1572-0502 | |||
| IIFT |
cell nuclei (ANA global test) |
HEp-2 cells liver (2 BIOCHIPs per field) |
human monkey |
IgG IgG IgG IgG IgG IgG IgG |
10 x 05 10 x 10 10 x 50 120 x 10 20 x 05 20 x 10 24 x 50 10 x 05 10 x 10 10 x 50 20 x 05 20 x 10 |
FA 1510-1005-1 FA 1510-1010-1 FA 1510-1050-1 FA 1510-12010-1 FA 1510-2005-1 FA 1510-2010-1 FA 1510-2450-1 FB 1510-1005-1 FB 1510-1010-1 FB 1510-1050-1 FB 1510-2005-1 FB 1510-2010-1 |
|
| IIFT |
cell nuclei (ANA) mitochondria (AMA) |
HEp-2 cells kidney (2 BIOCHIPs per field) |
human rat |
IgG IgG |
10 x 05 10 x 10 10 x 05 10 x 10 |
FA 1510-1005-2 FA 1510-1010-2 FB 1510-1005-2 FB 1510-1010-2 |
|
| IIFT |
cell nuclei (ANA global test) |
HEp-20-10 cells liver (2 BIOCHIPs per field) |
human monkey |
IgG IgG IgG IgG IgG IgG IgG |
10 x 05 10 x 10 10 x 50 120 x 10 20 x 05 20 x 10 24 x 50 10 x 05 10 x 10 10 x 50 20 x 05 20 x 10 |
FA 1512-1005-1 FA 1512-1010-1 FA 1512-1050-1 FA 1512-12010-1 FA 1512-2005-1 FA 1512-2010-1 FA 1512-2450-1 FB 1512-1005-1 FB 1512-1010-1 FB 1512-1050-1 FB 1512-2005-1 FB 1512-2010-1 |
|
| IIFT |
cell nuclei (ANA) mitochondria (AMA) |
HEp-20-10 cells kidney (2 BIOCHIPs per field) |
human rat |
IgG IgG IgG |
10 x 05 10 x 10 10 x 50 10 x 05 10 x 10 10 x 50 |
FA 1512-1005-2 FA 1512-1010-2 FA 1512-1050-2 FB 1512-1005-2 FB 1512-1010-2 FB 1512-1050-2 |
|
| IIFT | cell nuclei (ANA) | HEp-2 cells | human | IgG IgG IgG IgG IgG IgG |
10 x 05 10 x 10 10 x 50 120 x 10 20 x 05 20 x 10 10 x 05 10 x 10 10 x 50 20 x 05 20 x 10 |
FA 1520-1005 FA 1520-1010 FA 1520-1050 FA 1520-12010 FA 1520-2005 FA 1520-2010 FB 1520-1005 FB 1520-1010 FB 1520-1050 FB 1520-2005 FB 1520-2010 |
|
| IIFT | cell nuclei (ANA) | HEp-20-10 cells | human | IgG IgG IgG IgG |
10 x 05 10 x 10 20 x 05 20 x 10 10 x 05 10 x 10 20 x 05 20 x 10 |
FA 1522-1005 FA 1522-1010 FA 1522-2005 FA 1522-2010 FB 1522-1005 FB 1522-1010 FB 1522-2005 FB 1522-2010 |
|
| IIFT | dsDNA | flagellates | Crithidia luciliae | IgG IgG IgG IgG |
10 x 05 10 x 10 20 x 05 20 x 10 10 x 05 10 x 10 20 x 05 20 x 10 |
FA 1572-1005 FA 1572-1010 FA 1572-2005 FA 1572-2010 FB 1572-1005 FB 1572-1010 FB 1572-2005 FB 1572-2010 |
|
| IIFT | dsDNA (sensitive) | flagellates | Crithidia luciliae | IgG IgG IgG IgG |
10 x 05 10 x 10 20 x 05 20 x 10 |
FA 1572-1005-1 FA 1572-1010-1 FA 1572-2005-1 FA 1572-2010-1 |
|
| IIFT |
cell nuclei (ANA) EUROPattern cell nuclei (ANA) |
HEp-2 cells liver (2 BIOCHIPs per field) |
human monkey |
IgG PI IgG PI IgG PI IgG PI IgG PI IgG PI IgG PI IgG PI |
10 x 05 10 x 10 120 x 10 20 x 05 20 x 10 24 x 50 10 x 50 20 x 10 |
FC 1510-1005-1 FC 1510-1010-1 FC 1510-12010-1 FC 1510-2005-1 FC 1510-2010-1 FC 1510-2450-1 FW 1510-1050-1 FW 1510-2010-1 |
|
| IIFT |
cell nuclei (ANA) EUROPattern cell nuclei (ANA) |
HEp-20-10 cells liver (2 BIOCHIPs per field) |
human monkey |
IgG PI IgG PI IgG PI IgG PI IgG PI IgG PI IgG PI IgG PI IgG PI IgG PI IgG PI |
10 x 05 10 x 10 10 x 50 120 x 10 20 x 05 20 x 10 24 x 50 10 x 05 10 x 10 10 x 50 20 x 10 |
FC 1512-1005-1 FC 1512-1010-1 FC 1512-1050-1 FC 1512-12010-1 FC 1512-2005-1 FC 1512-2010-1 FC 1512-2450-1 FW 1512-1005-1 FW 1512-1010-1 FW 1512-1050-1 FW 1512-2010-1 |
|
| IIFT |
cell nuclei (ANA) EUROPattern mitochondria (AMA) |
HEp-20-10 cells kidney (2 BIOCHIPs per field) |
human rat |
IgG PI IgG PI IgG PI |
10 x 05 120 x 10 |
FC 1512-1005-2 FC 1512-12010-2 FC 1512-2450-2 |
|
| IIFT |
cell nuclei (ANA) EUROPattern |
HEp-2 cells | human | IgG PI IgG PI IgG PI IgG PI IgG PI IgG PI IgG PI IgG PI IgG PI IgG PI IgG PI IgG PI |
10 x 05 10 x 10 10 x 50 120 x 10 20 x 05 20 x 10 24 x 50 10 x 05 10 x 10 10 x 50 20 x 05 20 x 10 |
FC 1520-1005 FC 1520-1010 FC 1520-1050 FC 1520-12010 FC 1520-2005 FC 1520-2010 FC 1520-2450 FW 1520-1005 FW 1520-1010 FW 1520-1050 FW 1520-2005 FW 1520-2010 |
|
| IIFT |
cell nuclei (ANA) EUROPattern |
HEp-20-10 cells | human | IgG PI IgG PI IgG PI IgG PI IgG PI IgG PI IgG PI IgG PI IgG PI |
10 x 05 10 x 10 10 x 50 120 x 10 20 x 05 20 x 10 10 x 05 20 x 05 20 x 10 |
FC 1522-1005 FC 1522-1010 FC 1522-1050 FC 1522-12010 FC 1522-2005 FC 1522-2010 FW 1522-1005 FW 1522-2005 FW 1522-2010 |
|
| IIFT |
dsDNA EUROPattern |
flagellates | Crithidia luciliae | IgG EB IgG EB IgG EB IgG EB |
10 x 05 10 x 10 20 x 05 20 x 10 |
FC 1572-1005 FC 1572-1010 FC 1572-2005 FC 1572-2010 |
|
| IIFT |
dsDNA (sensitive) EUROPattern |
flagellates | Crithidia luciliae | IgG EB IgG EB IgG EB IgG EB IgG EB |
10 x 05 10 x 10 120 x 10 20 x 05 20 x 10 |
FC 1572-1005-1 FC 1572-1010-1 FC 1572-12010-1 FC 1572-2005-1 FC 1572-2010-1 |
|
| ELISA | Anti-Histones ELISA (IgG) |
antigen-coated microplate wells |
native, highly purified histones, bovine thymus |
2/20/200 RU/ml | IgG |
96 x 01 |
EA 1560-9601 G |
| ELISA |
Anti-dsDNA ELISA (IgG) double-stranded DNA |
antigen-coated microplate wells |
highly purified genomic double-stranded DNA |
10/100/800 IU/ml | IgG |
96 x 01 |
EA 1571-9601 G |
| ELISA | Anti-dsDNA-NcX ELISA (IgG) |
antigen-coated microplate wells |
highly purified genomic double-stranded DNA, complexed with nucleosomes |
10/100/800 IU/ml | IgG |
96 x 01 |
EA 1572-9601 G |
| ELISA | Anti-Nucleosomes ELISA (IgG) |
antigen-coated microplate wells |
native, nucleosomes, calf thymus |
2/20/200 RU/ml | IgG |
96 x 01 |
EA 1574-9601 G |
| ELISA |
Anti-ENA SLE Profile 2-ELISA (IgG) (dsDNA, histones, nucleosomes, nRNP/Sm, Sm, SS-A, SS-B, Scl-70 separately) |
antigen-coated microplate wells |
see individual ELISA | semi-quantitative | IgG |
12 x 08 |
EA 1590-1208-12 G |
| ELISA |
Anti-ENA ProfilePlus 2 ELISA (IgG) (ribosomal P-proteins, nRNP/Sm, Sm, SS-A, SS-B, Scl-70, Jo-1, centromeres, separately) |
antigen-coated microplate wells |
see individual ELISA | semi-quantitative | IgG |
12 x 08 |
EA 1590-1208-2 G |
| ELISA |
ANA Screen 11 ELISA (IgG) (antigen mixture: PCNA, PM-Scl, ribosomal P-proteins, nRNP/Sm, Sm, SS-A, Ro-52, SS-B, Scl-70, Jo-1, centromeres) |
antigen-coated microplate wells |
see individual ELISA | semi-quantitative | IgG |
96 x 01 |
EA 1590-9601-11 G |
| ELISA |
ANA Screen 9 ELISA (IgG) (antigen mixture: PCNA, PM-Scl, ribosomal P-proteins, nRNP/Sm, Sm, SS-A, SS-B, Scl-70, Jo-1) |
antigen-coated microplate wells |
see individual ELISA | semi-quantitative | IgG |
96 x 01 |
EA 1590-9601-14 G |
| ELISA |
ANA Screen ELISA (IgG) (antigen mixture: dsDNA, histones, ribosomal P-proteins, nRNP/Sm, Sm, SS-A, SS-B, Scl-70, Jo-1, centromeres) |
antigen-coated microplate wells |
see individual ELISA | semi-quantitative | IgG |
96 x 01 |
EA 1590-9601-8 G |
| ELISA |
Anti-ENA Pool ELISA (IgG) (antigen mixture: nRNP/Sm, Sm, SS-A, SS-B, Scl-70, ribosomal P-proteins, Ro-52) |
antigen-coated microplate wells |
see individual ELISA | semi-quantitative | IgG |
96 x 01 |
EA 1590-9601-9 G |
| ELISA | Anti-Sm ELISA (IgG) |
antigen-coated microplate wells |
native, U2-, U4-, U5-, U6-nRNP, incl. B, B', D, E, F, G, calf thymus |
2/20/200 RU/ml | IgG |
96 x 01 |
EA 1593-9601 G |
| EUROLINE |
EUROLINE ANA Profile 23 (IgG) (nucleosomes, dsDNA, histones, SS-A, Ro-52, SS-B, nRNP/Sm, Sm, Mi-2 alpha, Mi-2 beta, Ku, CENP A, CENP B, Sp100, PML, Scl-70, PM-Scl100, PM-Scl75, RP11, RP155, gp210, PCNA, DFS70 separately) |
EUROLINE | IgG IgG IgG |
16 x 01 50 x 01 64 x 01 |
DL 1590-1601-23 G DL 1590-5001-23 G DL 1590-6401-23 G |
||
| EUROLINE |
EUROLINE ANA Profile 3 (IgG) (nRNP/Sm, Sm, SS-A, Ro-52, SS-B, Scl-70, PM-Scl, Jo-1, CENP B, PCNA, dsDNA, nucleosomes, histones, ribosomal P-proteins, AMA M2 separately) |
EUROLINE | IgG IgG IgG |
16 x 01 50 x 01 64 x 01 |
DL 1590-1601-3 G DL 1590-5001-3 G DL 1590-6401-3 G |
||
| EUROLINE |
EUROLINE ANA Profile 3 plus DFS70 (IgG) (nRNP/Sm, Sm, SS-A, Ro-52, SS-B, Scl-70, PM-Scl, Jo-1, CENP B, PCNA, dsDNA, nucleosomes, histones, ribosomal P-proteins, AMA M2, DFS70 separately) |
EUROLINE | IgG IgG IgG |
16 x 01 50 x 01 64 x 01 |
DL 1590-1601-30 G DL 1590-5001-30 G DL 1590-6401-30 G |
||
| EUROLINE |
EUROLINE ANA Profile et Mi-2 et Ku (IgG) (Mi-2, Ku, nRNP/Sm, Sm, SS-A, Ro-52, SS-B, Scl-70, PM-Scl, Jo-1, CENP B, PCNA, dsDNA, nucleosomes, histones, ribosomal P-proteins, AMA M2 separately) |
EUROLINE | IgG IgG |
16 x 01 64 x 01 |
DL 1590-1601-31 G DL 1590-6401-31 G |
||
| EUROLINE |
EUROLINE ANA Profile et Mi-2, Ku, DFS70 (IgG) (Mi-2, Ku, nRNP/Sm, Sm, SS-A, Ro-52, SS-B, Scl-70, PM-Scl100, Jo-1, CENP B, PCNA, dsDNA, nucleosomes, histones, ribosomal P-proteins, AMA M2, DFS70 separately) |
EUROLINE | IgG IgG IgG |
16 x 01 50 x 01 64 x 01 |
DL 1590-1601-33 G DL 1590-5001-33 G DL 1590-6401-33 G |
||
| EUROLINE |
EUROLINE ANA Profile 5 (IgG) (nRNP/Sm, Sm, RNP70, RNPA, RNPC, SS-A, Ro-52, SS-B, Scl-70, PM-Scl, Jo-1, CENP B, PCNA, dsDNA, nucleosomes, histones, ribosomal P-proteins, AMA M2 separately) |
EUROLINE | IgG IgG |
16 x 01 64 x 01 |
DL 1590-1601-5 G DL 1590-6401-5 G |
||
| EUROLINE |
EUROLINE ANA-Profile 1 (IgG) (nRNP/Sm, Sm, SS-A, Ro-52, SS-B, Scl-70, Jo-1, CENP B, dsDNA, nucleosomes, histones, ribosomal P-proteins separately) |
EUROLINE | IgG IgG IgG |
16 x 01 50 x 01 64 x 01 |
DL 1590-1601-8 G DL 1590-5001-8 G DL 1590-6401-8 G |
||
| ChLIA | IDS ANA Screen | antigenic coated magnetic particles | dsDNA, Centromere B, SS-A/Ro (60 kDa and 52 kDa), SS-B/La, Sm, U1-snRNP (70 kDa, A and C), Scl-70, Jo-1 |
qualitative |
100 x 01 |
IS-AI10011 | |
| ChLIA | IDS ENA Screen | antigenic coated magnetic particles | SS-A/Ro (60 kDa and 52 kDa), SS-B/La, Sm, U1-snRNP (70 kDa, A and C), Scl-70, Jo-1 |
qualitative |
100 x 01 |
IS-AI10021 | |
| ChLIA | IDS ANA Screen Control Set | 3 x 1.5 ml Control 1/2 | human serum |
2 concentrations |
IS-AI10301 | ||
| ChLIA | IDS dsDNA IgG | antigenic coated magnetic particles | dsDNA |
quantitative |
100 x 01 |
IS-AI11011 | |
| ChLIA | IDS SS-A/Ro | antigenic coated magnetic particles | SS-A/Ro |
quantitative |
50 x 01 |
IS-AI11021 | |
| ChLIA | IDS SS-A/Ro 60 kDa | antigenic coated magnetic particles | SS-A/Ro 60 kDa |
quantitative |
50 x 01 |
IS-AI11041 | |
| ChLIA | IDS SS-B/La | antigenic coated magnetic particles | SS-B/La |
quantitative |
50 x 01 |
IS-AI11051 | |
| ChLIA | IDS Sm | antigenic coated magnetic particles | Sm |
quantitative |
50 x 01 |
IS-AI11061 | |
| ChLIA | IDS U1-snRNP | antigenic coated magnetic particles | U1-snRNP (70 kDa, A, C) |
quantitative |
50 x 01 |
IS-AI11071 | |
| ChLIA | IDS ANA Control Set | 3 x 1.5 ml Control 1/2 | human serum |
2 concentrations |
IS-AI11301 | ||
| ELISA | Anti-ribosomal P Proteins ELISA (IgG) |
antigen-coated microplate wells |
native, P0/P1/P2 of the 60S ribosomal subunit, calf thymus |
2/20/200 RU/ml | IgG |
96 x 01 |
EA 1641-9601 G |
|
* For research use only, not for in vitro diagnostic use in the sense of EU directive 98/79/EC. 1 Product manufactured by third party. Please contact your local Euroimmun representative for more information. | |||||||