Sexually transmitted infections

Clinical information

Sexually transmitted infections (STIs) can be caused by bacteria (e. g. Treponema pallidum, Chlamydia trachomatis, Neisseria gonorrhoeae, Mycoplasma), viruses (e. g. human papillomavirus (HPV), HSV) or parasites (Trichomonas vaginalis) that are transmitted from person to person through vaginal, anal or oral sex. The course, symptoms and consequences of STIs can vary considerably depending on the causative pathogen. In many cases, the infection is asymptomatic, so that it goes undetected for a long time and is only diagnosed when it has become chronic. Infections with these pathogens often cause inflammation of the urogenital tract which, if left untreated, can spread upwards and lead to infertility, among others. Some pathogens cause cell changes that can sometimes lead to cervical cancer.

In addition to the direct consequences for the patient, infections with most sexually transmitted pathogens during pregnancy can lead to intrauterine death, premature birth or damage to the foetus. Moreover, many pathogens can be transmitted to the newborn during birth, causing severe postnatal infections.

Diagnostics

The most commonly used methods for detecting STIs are direct methods, where the pathogen is detected by PCR or culture, and indirect methods, i. e. detection of pathogen-specific antibodies. Since detection by culture is particularly time-consuming and difficult for Chlamydia, Mycoplasma, Ureaplasma and Treponema, other detection methods, e. g. PCR-based and/or serological procedures, are generally recommended or required for these pathogens.

Methods

ChLIA (9)

ELISA (16)

EUROArray (2)

EUROLINE (4)

IIFT (5)

WESTERNBLOT (7)

Technology	Parameter	Substrate	Species	Calibration	Ig Class	Format	Order No.
ELISA	CSQ pair of controls anti-HSV-1/2 Pool (IgG)				IgG	02 x 20	CK 2531-0220-1 L G
ELISA	CSF: Anti-HSV-1/2 Pool ELISA (IgG) herpes simplex virus Sample type: CSF/serum pair	antigen-coated microplate wells	native antigens from HSV-1 and HSV-2	5/25/50/100/175/230 U/ml	IgG	96 x 01	EI 2531-9601-1 L G
ELISA	CSQ pair of controls anti-Treponema pallidum (IgG)				IgG	02 x 20	CK 2111-0220-L G
ELISA	CSF: Anti-Treponema pallidum ELISA (IgG) Sample type: CSF/serum pair	antigen-coated microplate wells	recombinant antigens 15 kDa, 17 kDa, 47 kDa, 42 kDa (TmpA)	5/25/50/100 U	IgG	96 x 01	EI 2111-9601-L G
ELISA	Anti-HSV-1/2 Pool ELISA (IgG) herpes simplex virus native antigens from HSV-1 and HSV-2	antigen-coated microplate wells	native antigens from HSV-1 and HSV-2	2/20/200 RU/ml	IgG	96 x 01	EI 2531-9601-1 G
ELISA	Anti-HSV-1/2 Pool ELISA (IgM) herpes simplex virus native antigens from HSV-1 and HSV-2	antigen-coated microplate wells	native antigens from HSV-1 and HSV-2	semi-quantitative	IgM	96 x 01	EI 2531-9601-1 M
ELISA	Anti-HSV-1 (gC1) ELISA (IgG) herpes simplex virus 1 recombinant glycoprotein C1 from HSV-1	antigen-coated microplate wells	recombinant glycoprotein C1	2/20/200 RU/ml	IgG	96 x 01	EI 2531-9601-2 G
ELISA	Anti-HSV-2 (gG2) ELISA (IgG) herpes simplex virus 2 recombinant glycoprotein G2 from HSV-2	antigen-coated microplate wells	recombinant glycoprotein G2	2/20/200 RU/ml	IgG	96 x 01	EI 2532-9601-2 G
WESTERNBLOT	antibodies against Herpes simplex virus (HSV) IgG positive control				IgG	50 x 05	CW 2531-5005 G
WESTERNBLOT	Anti-HSV-1 / HSV-2 gG-2 EUROLINE-WB (IgG) Herpes simplex virus 1 (HSV-1) plus HSV-2 type-specific glycoprotein G2	Westernblot	whole antigen, SDS extract of HSV-1 plus purified gG2		IgG	16 x 01	DY 2531-1601-1 G
WESTERNBLOT	Anti-HSV-1 / HSV-2 gG-2 EUROLINE-WB (IgM) Herpes simplex virus 1 (HSV-1) plus HSV-2 type-specific glycoprotein G2	Westernblot	whole antigen, SDS extract of HSV-1 plus purified gG2		IgM	16 x 01	DY 2531-1601-1 M
ChLIA	IDS HSV-1 IgG	antigenic coated magnetic particles	gG1 antigen	quantitative		100 x 01	IS-ID5601¹
ChLIA	IDS HSV-2 IgG	antigenic coated magnetic particles	gG2 antigen	quantitative		100 x 01	IS-ID5602¹
ChLIA	IDS HSV 1/2 IgG Control Set	3 x 1.5 ml Control 1/2	human serum			2 concentrations	IS-ID5630¹
ChLIA	IDS HSV 1/2 IgM	antigenic coated magnetic particles	gG1 and gG2 antigens	quantitative		100 x 01	IS-ID5701¹
ChLIA	IDS HSV 1/2 IgM Control Set	3 x 1.5 ml Control 1/2	human serum			2 concentrations	IS-ID5730¹
ChLIA	Anti-Herpes simplex virus 1 ChLIA (IgG)	Antigen-coated magnetic particles	recombinant gG1	quantitative	IgG	100 x 1	LI 2531-10010 G
ChLIA	Anti-Herpes simplex virus 2 ChLIA (IgG)	Antigen-coated magnetic particles	rekombinant gG2	quantitative	IgG	100 x 1	LI 2532-10010 G
ChLIA	Control set Anti-HSV 1 ChLIA (IgG)	2 x 0.5 ml control 1/2			IgG	02 x 02	LR 2531-20210 G
ChLIA	Control set Anti-HSV 2 ChLIA (IgG)	2 x 0.5 ml control 1/2			IgG	02 x 02	LR 2532-20210 G
EUROArray	EUROArray STI - 11						MN 2830-0505 MN 2830-0803 MN 2830-1005 MN 2830-2005
EUROArray	EUROArray HPV						MN 2540-0505 MN 2540-0803 MN 2540-1005 MN 2540-2005
ELISA	Anti-Chlamydia trachomatis Advanced ELISA (IgA)			semi-quantitative	IgA	96 x 01	EI 2191-9601-1 A
ELISA	Anti-Chlamydia trachomatis Advanced ELISA (IgG)			quantitative	IgG	96 x 01	EI 2191-9601-1 G
IIFT	Treponema pallidum (FTA-ABS)	bacterial smear verification BIOCHIP (2 BIOCHIPs per field)	T. pallidum		IgG IgM IgG IgM	10 x 05 10 x 05 10 x 10 10 x 10	FI 2111-1005 G FI 2111-1005 M FI 2111-1010 G FI 2111-1010 M
IIFT	Treponema pallidum (FTA-ABS)	bacterial smears verification BIOCHIP (3 BIOCHIPs per field)	T. pallidum T. phagedenis		IgG IgM IgG IgM	10 x 05 10 x 05 10 x 10 10 x 10	FI 2112-1005 G FI 2112-1005 M FI 2112-1010 G FI 2112-1010 M
IIFT	Anti-Chlamydia MIF Chlamydia trachomatis Chlamydia pneumoniae Chlamydia psittaci	4 BIOCHIPs per field: elementary bodies and non-infected cells	EU 40 EU 40 EU 40		IgA EB IgG EB IgM EB IgA EB IgG EB IgM EB	10 x 05 10 x 05 10 x 05 10 x 10 10 x 10 10 x 10	FI 2191-1005-3 A FI 2191-1005-3 G FI 2191-1005-3 M FI 2191-1010-3 A FI 2191-1010-3 G FI 2191-1010-3 M
IIFT	Chlamydia trachomatis	elementary bodies (MIF) non-infected cells (2 BIOCHIPs per field)	EU 40 EU 40		IgA EB IgG EB IgM EB	10 x 05 10 x 05 10 x 05	FI 2191-1005-80 A FI 2191-1005-80 G FI 2191-1005-80 M
IIFT	Anti-Chlamydia MIF EUROPattern Chlamydia trachomatis Chlamydia pneumoniae Chlamydia psittaci	4 BIOCHIPs per field: elementary bodies and non-infected cells	EU 40 EU 40 EU 40		IgA EB IgG EB IgM EB IgA EB IgG EB IgM EB	10 x 05 10 x 05 10 x 05 10 x 10 10 x 10 10 x 10	FR 2191-1005-3 A FR 2191-1005-3 G FR 2191-1005-3 M FR 2191-1010-3 A FR 2191-1010-3 G FR 2191-1010-3 M
ELISA	Anti-Treponema pallidum ELISA (IgG)	antigen-coated microplate wells	recombinant antigens 15 kDa, 17 kDa, 47 kDa, 42 kDa (TmpA)	2/20/200 RU/ml	IgG	96 x 01	EI 2111-9601 G
ELISA	Anti-Treponema pallidum ELISA (IgM)	antigen-coated microplate wells	recombinant antigens 15 kDa, 17 kDa, 47 kDa, 42 kDa (TmpA)	semi-quantitative	IgM	96 x 01	EI 2111-9601 M
ELISA	Anti-Treponema pallidum ELISA 2.0 (IgGM)			200/50/20/2 RU/ml	IgGM	96 x 01	EI 2111-9601-2 O
ELISA	Anti-Chlamydia trachomatis ELISA (IgA)	antigen-coated microplate wells	native MOMP antigen from C. trachomatis	semi-quantitative	IgA	96 x 01	EI 2191-9601 A
ELISA	Anti-Chlamydia trachomatis ELISA (IgG)	antigen-coated microplate wells	native MOMP antigen from C. trachomatis	2/20/200 RU/ml	IgG	96 x 01	EI 2191-9601 G
ELISA	Anti-Chlamydia trachomatis ELISA (IgM)	antigen-coated microplate wells	native MOMP antigen from C. trachomatis	semi-quantitative	IgM	96 x 01	EI 2191-9601 M
EUROLINE	positive control serum: IgG, human, 50x concentrated for Treponema pallidum				IgG	05 x 07	CL 2111-0507 G
EUROLINE	positive control serum: IgM, human, 50x concentrated for Treponema pallidum				IgM	05 x 07	CL 2111-0507 M
EUROLINE	EUROLINE Anti-Treponema pallidum (IgG) (TpN15, TpN17, TmpA, TpN47 separately)	EUROLINE			IgG IgG	16 x 01 64 x 01	DN 2111-1601 G DN 2111-6401 G
EUROLINE	EUROLINE Anti-Treponema pallidum (IgM) (TpN15, TpN17, TmpA, TpN47 separately)	EUROLINE			IgM IgM	16 x 01 64 x 01	DN 2111-1601 M DN 2111-6401 M
WESTERNBLOT	antibodies against Treponema pallidum IgG positive control				IgG	50 x 05	CW 2111-5005 G
WESTERNBLOT	antibodies against Treponema pallidum IgM positive control				IgM	50 x 05	CW 2111-5005 M
WESTERNBLOT	Anti-Treponema pallidum WESTERNBLOT (IgG)	Westernblot	15 kDa, 17 kDa, 45 kDa (tmpA), 47 kDa		IgG IgG	16 x 01 24 x 01	DY 2111-1601 G DY 2111-2401 G
WESTERNBLOT	Anti-Treponema pallidum WESTERNBLOT (IgM)	Westernblot	15 kDa, 17 kDa, 45 kDa (tmpA), 47 kDa		IgM IgM	16 x 01 24 x 01	DY 2111-1601 M DY 2111-2401 M
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