Clinical information
Over the past years, a global spread of many new viruses and other pathogens has been observed. The associated diseases are referred to as “emerging infectious diseases”. This term refers to infectious diseases that occur for the first time in a population or have increased rapidly in incidence or regional distribution. Viruses transmitted by arthropods, also known as arboviruses, are among the most common causative agents of diseases in humans worldwide and have posed a growing problem over the past decades. Arboviruses have a great ability to mutate and adapt, which is why they often cause outbreaks. Besides dengue and chikungunya fever, Zika fever is particularly noteworthy, which spread to large parts of South America in 2015/2016. However, also in moderate climates – like in Europe – arboviruses such as West Nile virus and chikungunya virus have caused seasonal outbreaks in the past. The clinical courses of diseases caused by arboviruses are very similar, so that diagnosis usually cannot be based on the clinical picture alone.
In addition to the above-mentioned arboviruses, there are various other pathogens that cause large outbreaks and could develop into a significant global health problem, such as SARS-CoV-2, which recently led to a pandemic.
Diagnostics
Diagnosis of these diseases is particularly challenging, as there are often no commercial diagnostic test systems available for the corresponding parameters. Generally, an infection with a causative agent of an emerging disease is diagnosed based on clinical and epidemiological criteria as well as laboratory findings. Laboratory diagnostics use both direct and indirect detection methods and are particularly important for testing travellers after trips to endemic areas and for screening large population groups in the case of an epidemic or a pandemic.
Methods
| Technology | Parameter | Substrate | Species | Calibration | Ig Class | Format | Order No. |
|---|---|---|---|---|---|---|---|
| ELISA |
Anti-TBE Virus CSF ELISA 2.0 (IgG) tick-borne encephalitis virus |
antigen-coated microplate wells |
TBE viral proteins | 5/25/50/100/175/230 U/ml | IgG |
96 x 01 |
EI 2661-9601-2L G |
| ELISA |
Anti-TBE Virus CSF ELISA 2.0 (IgM) tick-borne encephalitis virus |
antigen-coated microplate wells |
TBE viral proteins | IgM |
96 x 01 |
EI 2661-9601-2L M | |
| IIFT | West Nile virus (WNV) |
infected and non- infected cells (2 BIOCHIPs per field) |
EU 14 | IgG IgM IgG IgM |
10 x 05 10 x 05 10 x 10 10 x 10 |
FI 2662-1005 G FI 2662-1005 M FI 2662-1010 G FI 2662-1010 M |
|
| IIFT | Japanese encephalitis virus (JEV) |
infected and non- infected cells (2 BIOCHIPs per field) |
EU 14 | IgG IgM |
10 x 05 10 x 05 |
FI 2663-1005 G FI 2663-1005 M |
|
| IIFT | Yellow fever virus (YFV) |
infected and non- infected cells (2 BIOCHIPs per field) |
EU 14 | IgG IgM IgG IgM |
10 x 05 10 x 05 10 x 10 10 x 10 |
FI 2665-1005 G FI 2665-1005 M FI 2665-1010 G FI 2665-1010 M |
|
| IIFT |
Mosaic Dengue virus types 1 - 4 (DENV) |
4 BIOCHIPs per field: infected cells |
EU 14 |
IgG IgM IgG IgM IgG IgM |
10 x 05 10 x 05 10 x 10 10 x 10 20 x 05 20 x 05 |
FI 266a-1005-1 G FI 266a-1005-1 M FI 266a-1010-1 G FI 266a-1010-1 M FI 266a-2005-1 G FI 266a-2005-1 M |
|
| IIFT |
Sandfly fever virus Mosaic 1 types Sicilian, Naples, Toscana, Cyprus |
4 BIOCHIPs per field: infected cells |
EU 14 |
IgG IgM IgG IgM |
10 x 05 10 x 05 10 x 10 10 x 10 |
FI 277a-1005-1 G FI 277a-1005-1 M FI 277a-1010-1 G FI 277a-1010-1 M |
|
| IIFT |
Hantavirus Mosaic 1 types Hantaan (HTNV), Sin Nombre (SNV), Puumala (PUUV), Dobrava (DOBV), Seoul (SEOV), Saaremaa (SAAV) |
6 BIOCHIPs per field: infected cells |
EU 14 |
IgG IgM IgG IgM |
10 x 05 10 x 05 10 x 10 10 x 10 |
FI 278h-1005-1 G FI 278h-1005-1 M FI 278h-1010-1 G FI 278h-1010-1 M |
|
| IIFT |
Hantavirus Mosaic 2 Eurasia types Hantaan (HTNV), Puumala (PUUV), Dobrava (DOBV), Seoul (SEOV), Saaremaa (SAAV) |
6 BIOCHIPs per field: infected and non- infected cells |
EU 14 |
IgG IgM IgG IgM |
10 x 05 10 x 05 10 x 10 10 x 10 |
FI 278h-1005-2 G FI 278h-1005-2 M FI 278h-1010-2 G FI 278h-1010-2 M |
|
| IIFT |
Hantavirus Mosaic 3: America types Sin Nombre (SNV), Andes (ANDV) |
2 BIOCHIPs per field: infected cells |
EU 14 |
IgG IgM |
10 x 05 10 x 05 |
FI 278m-1005-3 G FI 278m-1005-3 M |
|
| IIFT | Chikungunya virus (CHIKV) |
infected and non- infected cells (2 BIOCHIPs per field) |
EU 14 | IgG IgM IgG IgM IgG IgM |
10 x 05 10 x 05 10 x 10 10 x 10 20 x 05 20 x 05 |
FI 293a-1005 G FI 293a-1005 M FI 293a-1010 G FI 293a-1010 M FI 293a-2005 G FI 293a-2005 M |
|
| IIFT |
Arbovirus Fever Mosaic 1 Chikungunya virus (CHIKV) Japanese encephalitis virus (JEV) Dengue virus types 1 - 4 (DENV) |
6 BIOCHIPs per field: infected cells infected cells infected cells |
EU 14 EU 14 EU 14 |
IgG IgM IgG IgM |
10 x 05 10 x 05 10 x 10 10 x 10 |
FI 293a-1005-1 G FI 293a-1005-1 M FI 293a-1010-1 G FI 293a-1010-1 M |
|
| IIFT | Yellow fever virus (YFV) EUROPattern |
infected and non- infected cells (2 BIOCHIPs per field) |
EU 14 | IgG PI IgM PI |
10 x 05 10 x 05 |
FR 2665-1005 G FR 2665-1005 M |
|
| IIFT |
Mosaic Dengue virus types 1 - 4 (DENV) EUROPattern |
4 BIOCHIPs per field: infected cells |
EU 14 |
IgG PI IgM PI IgG PI IgM PI |
10 x 05 10 x 05 10 x 10 10 x 10 |
FR 266a-1005-1 G FR 266a-1005-1 M FR 266a-1010-1 G FR 266a-1010-1 M |
|
| IIFT |
Sandfly fever virus Mosaic 1 EUROPattern types Sicilian, Naples, Toscana, Cyprus |
4 BIOCHIPs per field: infected cells |
EU 14 |
IgG PI IgM PI |
10 x 05 10 x 05 |
FR 277a-1005-1 G FR 277a-1005-1 M |
|
| IIFT |
Hantavirus Mosaic 1 EUROPattern types Hantaan (HTNV), Sin Nombre (SNV), Puumala (PUUV), Dobrava (DOBV), Seoul (SEOV), Saaremaa (SAAV) |
6 BIOCHIPs per field: infected cells |
EU 14 |
IgG PI IgM PI |
10 x 05 10 x 05 |
FR 278h-1005-1 G FR 278h-1005-1 M |
|
| IIFT |
Hantavirus Mosaic 3: America EUROPattern types Sin Nombre (SNV), Andes (ANDV) |
2 BIOCHIPs per field: infected cells |
EU 14 |
IgG PI IgM PI |
10 x 05 10 x 05 |
FR 278m-1005-3 G FR 278m-1005-3 M |
|
| IIFT | Chikungunya virus (CHIKV) EUROPattern |
infected and non- infected cells (2 BIOCHIPs per field) |
EU 14 | IgG PI IgM PI IgG PI IgM PI |
10 x 05 10 x 05 10 x 10 10 x 10 |
FR 293a-1005 G FR 293a-1005 M FR 293a-1010 G FR 293a-1010 M |
|
| ELISA |
Anti-West Nile Virus ELISA (IgG) WNV |
antigen-coated microplate wells |
detergent-extracted glycoprotein E from the membrane fraction of human cells |
2/20/200 RU/ml | IgG |
96 x 01 |
EI 2662-9601 G |
| ELISA |
Anti-West Nile Virus ELISA (IgM) WNV |
antigen-coated microplate wells |
detergent-extracted glycoprotein E from the membrane fraction of human cells |
semi-quantitative | IgM |
96 x 01 |
EI 2662-9601 M |
| ELISA |
Avidity: Anti-West Nile Virus ELISA (IgG) avidity determination |
antigen-coated microplate wells |
detergent-extracted glycoprotein E from the membrane fraction of human cells |
2/20/200 RU/ml | IgG |
96 x 01 |
EI 2662-9601-1 G |
| ELISA |
Anti-JEV ELISA (IgG) Japanese encephalitis virus |
antigen-coated microplate wells |
detergent-extracted glycoprotein E from the membrane fraction of human cells |
2/20/200 RU/ml | IgG |
96 x 01 |
EI 2663-9601 G |
| ELISA |
Anti-JEV ELISA (IgM) Japanese encephalitis virus |
antigen-coated microplate wells |
detergent-extracted glycoprotein E from the membrane fraction of human cells |
semi-quantitative | IgM |
96 x 01 |
EI 2663-9601 M |
| ELISA | Anti-Usutu Virus ELISA (IgG) |
antigen-coated microplate wells |
recombinant glycoprotein E of Usutu virus |
2/20/200 RU/ml | IgG |
96 x 01 |
EI 2667-9601 G |
| ELISA | Anti-Dengue Virus Type 1-4 ELISA (IgG) |
antigen-coated microplate wells |
preparation of Dengue virus particles and recombinant glycoprotein E of types 1-4 |
2/20/200 RU/ml | IgG |
96 x 01 |
EI 266a-9601-1 G |
| ELISA | Anti-Dengue Virus Type 1-4 ELISA (IgM) |
antigen-coated microplate wells |
preparation of Dengue virus particles and recombinant glycoprotein E of types 1-4 |
semi-quantitative | IgM |
96 x 01 |
EI 266a-9601-1 M |
| ELISA | Anti-Dengue Virus NS1 ELISA 2.0 (IgG) |
antigen-coated microplate wells |
recombinant NS1 antigen from Dengue virus |
IgG |
96 x 01 |
EI 266a-9601-3 G | |
| ELISA | Anti-Oropouche Virus ELISA (IgG) |
antigen-coated microplate wells |
recombinant Oropouche-nucleocapsid protein |
2/20/200 RU/ml | IgG |
96 x 01 |
EI 2771-9601 G |
| ELISA | Anti-Oropouche Virus ELISA (IgM) |
antigen-coated microplate wells |
recombinant Oropouche-nucleocapsid protein |
semi-quantitative | IgM |
96 x 01 |
EI 2771-9601 M |
| ELISA | Anti-Toscana virus ELISA (IgG) |
antigen-coated microplate wells |
recombinant N-protein from Toscana virus |
2/20/200 RU/ml | IgG |
96 x 01 |
EI 277c-9601 G |
| ELISA | Anti-Hanta Virus Pool 1 "Eurasia" ELISA (IgG) |
antigen-coated microplate wells |
recombinant nucleocapsid proteins from strains Hantaan HTNV, Dobrava DOBV, Puumala PUUV |
2/20/200 RU/ml | IgG |
96 x 01 |
EI 278h-9601-1 G |
| ELISA | Anti-Hanta Virus Pool 1 "Eurasia" ELISA (IgM) |
antigen-coated microplate wells |
recombinant nucleocapsid proteins from strains Hantaan HTNV, Dobrava DOBV, Puumala PUUV |
semi-quantitative | IgM |
96 x 01 |
EI 278h-9601-1 M |
| ELISA | Anti-Hanta Virus Pool 2 "America" ELISA (IgG) |
antigen-coated microplate wells |
recombinant nucleocapsid proteins from strains Andes ANDV and Sin Nombre SNV |
2/20/200 RU/ml | IgG |
96 x 01 |
EI 278h-9601-2 G |
| ELISA | Anti-Hanta Virus Pool 2 "America" ELISA (IgM) |
antigen-coated microplate wells |
recombinant nucleocapsid proteins from strains Andes ANDV and Sin Nombre SNV |
semi-quantitative | IgM |
96 x 01 |
EI 278h-9601-2 M |
| ELISA | Anti-Chikungunya Virus ELISA (IgG) |
antigen-coated microplate wells |
recombinant structural protein from Chikungunya virus |
2/20/200 RU/ml | IgG |
96 x 01 |
EI 293a-9601 G |
| ELISA | Anti-Chikungunya Virus ELISA (IgM) |
antigen-coated microplate wells |
recombinant structural protein from Chikungunya virus |
semi-quantitative | IgM |
96 x 01 |
EI 293a-9601 M |
| ELISA | Anti-Mayaro Virus ELISA (IgG) |
antigen-coated microplate wells |
recombinant structural protein from Mayaro virus |
2/20/200 RU/ml | IgG |
96 x 01 |
EI 295c-9601 G |
| ELISA | Anti-Mayaro Virus ELISA (IgM) |
antigen-coated microplate wells |
recombinant structural protein from Mayaro virus |
semi-quantitative | IgM |
96 x 01 |
EI 295c-9601 M |
| ELISA |
Dengue virus NS1 antigen detection (DENV) |
antibody-coated microplate wells |
Dengue virus NS1 (type 1-4) | 1/10/100 RU/ml |
96 x 01 |
EQ 266a-9601-1 | |
| IIFT | Zika virus (ZIKV) |
infected and non- infected cells (2 BIOCHIPs per field) |
EU 14 | IgG IgM IgG IgM |
10 x 05 10 x 05 10 x 10 10 x 10 |
FI 2668-1005 G FI 2668-1005 M FI 2668-1010 G FI 2668-1010 M |
|
| IIFT |
Arbovirus Fever Mosaic 2 Zika virus (ZIKV) Chikungunya virus (CHIKV) Dengue virus types 1 - 4 (DENV) |
6 BIOCHIPs per field: infected cells infected cells infected cells |
EU 14 EU 14 EU 14 |
IgG IgM IgG IgM |
10 x 05 10 x 05 10 x 10 10 x 10 |
FI 2668-1005-1 G FI 2668-1005-1 M FI 2668-1010-1 G FI 2668-1010-1 M |
|
| IIFT |
Arbovirus Profile 3 upper row : Zika virus (ZIKV) Chikungunya virus (CHIKV) Dengue virus types 1 - 4 (DENV) bottom row: TBE virus (TBEV) West Nile virus (WNV) Japanese encephalitis virus (JEV) Yellow fever virus (YFV) |
infected cells infected cells infected cells infected cells infected cells infected cells infected cells |
EU 14 EU 14 EU 14 EU 14 EU 14 EU 14 EU 14 |
IgG IgM |
10 x 05 10 x 05 |
FI 2668-1005-3 G FI 2668-1005-3 M |
|
| IIFT | Zika virus (ZIKV) EUROPattern |
infected and non- infected cells (2 BIOCHIPs per field) |
EU 14 | IgG PI IgM PI IgG PI IgM PI |
10 x 05 10 x 05 10 x 10 10 x 10 |
FR 2668-1005 G FR 2668-1005 M FR 2668-1010 G FR 2668-1010 M |
|
| IIFT |
Arbovirus Fever Mosaic 2 EUROPattern Zika virus (ZIKV) Chikungunya virus (CHIKV) Dengue virus types 1 - 4 (DENV) |
6 BIOCHIPs per field: infected cells infected cells infected cells |
EU 14 EU 14 EU 14 |
IgG PI IgM PI IgG PI IgM PI |
10 x 05 10 x 05 10 x 10 10 x 10 |
FR 2668-1005-1 G FR 2668-1005-1 M FR 2668-1010-1 G FR 2668-1010-1 M |
|
| ELISA | Anti-Zika Virus ELISA (IgG) |
antigen-coated microplate wells |
recombinant NS1 antigen from Zika virus |
2/20/200 RU/ml | IgG |
96 x 01 |
EI 2668-9601 G |
| ELISA | Anti-Zika Virus ELISA (IgM) |
antigen-coated microplate wells |
recombinant NS1 antigen from Zika virus |
semi-quantitative | IgM |
96 x 01 |
EI 2668-9601 M |
| ELISA | Anti-Zika Virus ELISA (IgAM) |
antigen-coated microplate wells |
specific NS1 antigen from Zika virus |
semi-quantitative | IgAM |
96 x 01 |
EI 2668-9601 Q |
| ELISA |
Anti-MERS-CoV ELISA (IgG) Middle east respiratory syndrome coronavirus |
antigen-coated microplate wells |
recombinant S1 antigen of MERS coronavirus (MERS-CoV S1) |
semi-quantitative | IgG |
96 x 01 |
EI 2604-9601 G |
| ELISA |
Anti-SARS-CoV-2 ELISA (IgA) Severe acute respiratory syndrome coronavirus 2 |
antigen-coated microplate wells |
recombinant S1 antigen of SARS-CoV-2 |
semi-quantitative | IgA |
96 x 01 |
EI 2606-9601 A |
| ELISA |
Anti-SARS-CoV-2 ELISA (IgG) Severe acute respiratory syndrome coronavirus 2 |
antigen-coated microplate wells |
recombinant S1 antigen of SARS-CoV-2 |
semi-quantitative | IgG |
96 x 01 |
EI 2606-9601 G |
| ELISA |
Anti-SARS-CoV-2 QuantiVac ELISA (IgG) Severe acute respiratory syndrome coronavirus 2 |
1/10/20/40/80/120 RU/mL | IgG |
96 x 01 |
EI 2606-9601-10 G | ||
| ELISA |
Anti-SARS-CoV-2 NCP ELISA (IgG) Severe acute respiratory syndrome coronavirus 2 nucleocapsid protein |
semi-quantitative | IgG |
96 x 01 |
EI 2606-9601-2 G | ||
| ChLIA | Anti-SARS-CoV-2 RBD ChLIA (IgG) | Antigen-coated magnetic particles | quantitative | IgG |
100 x 1 |
LI 2606-10010-1 G | |
| ChLIA | Control set Anti-SARS-CoV-2 RBD ChLIA (IgG) | 2 x 0.5 ml control 1/2 | IgG |
02 x 02 |
LR 2606-20210-1 G | ||
| ELISA | Anti-Crimean-Congo fever virus(CCHFV) ELISA (IgG) |
antigen-coated microplate wells |
recombinant protein from CCHFV |
2/20/200 RU/ml | IgG |
96 x 01 |
EI 279a-9601 G |
| ELISA | Anti-Crimean-Congo fever virus(CCHFV) ELISA (IgM) |
antigen-coated microplate wells |
recombinant protein from CCHFV |
semi-quantitative | IgM |
96 x 01 |
EI 279a-9601 M |
| IIFT | TBE virus (TBEV) |
infected and non- infected cells (2 BIOCHIPs per field) |
EU 14 | IgG IgM IgG IgM |
10 x 05 10 x 05 10 x 10 10 x 10 |
FI 2661-1005 G FI 2661-1005 M FI 2661-1010 G FI 2661-1010 M |
|
| IIFT |
Flavivirus Mosaic 1 TBE virus (TBEV) West Nile virus (WNV) Japanese encephalitis virus (JEV) Yellow fever virus (YFV) |
4 BIOCHIPs per field: infected cells infected cells infected cells infected cells |
EU 14 EU 14 EU 14 EU 14 |
IgG IgM IgG IgM |
10 x 05 10 x 05 10 x 10 10 x 10 |
FI 2661-1005-1 G FI 2661-1005-1 M FI 2661-1010-1 G FI 2661-1010-1 M |
|
| IIFT |
Flavivirus Profile 2 upper row: TBE virus (TBEV) West Nile virus (WNV) Japanese encephalitis virus (JEV) Yellow fever virus (YFV) bottom row: Dengue virus types 1 - 4 (DENV) |
infected cells infected cells infected cells infected cells infected cells |
EU 14 EU 14 EU 14 EU 14 EU 14 |
IgG IgM IgG IgM |
10 x 05 10 x 05 20 x 05 20 x 05 |
FI 2661-1005-2 G FI 2661-1005-2 M FI 2661-2005-2 G FI 2661-2005-2 M |
|
| ELISA |
Anti-TBE Virus ELISA 2.0 (IgG) tick-borne encephalitis virus |
antigen-coated microplate wells |
TBE viral proteins | IgG |
96 x 01 |
EI 2661-9601-2 G | |
| ELISA |
Anti-TBE Virus ELISA 2.0 (IgM) tick-borne encephalitis virus |
antigen-coated microplate wells |
semi-quantitative | IgM |
96 x 01 |
EI 2661-9601-2 M | |
|
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