Neurofilament (pNf-H)

Motor neuron diseases (MND) are a group of neurodegenerative diseases that are characterised by degeneration of the upper and lower motor neurons. With an incidence of around 2/100.000 per year, amyotrophic lateral sclerosis (ALS) is the most common motor neuron disease.

In the early disease stage, ALS patients experience first unspecific symptoms such as muscle weakness or cramps in arms or legs or trouble swallowing and speaking. When the disease progresses, the symptoms occur all over the body and increase in intensity. Finally, the patient experiences a complete loss of autonomy and the ability to communicate.

ALS has no cure and a large proportion of the patients die 3 to 5 years following the first symptoms. While mutations in different genes can be found, which account for 5 to 10% of familial ALS cases, the underlying cause of sporadic ALS remains unknown despite intensive research.

A promising biomarker for ALS is the phosphorylated heavy chain of neurofilament (neurofilament heavy, pNf-H), which is a main component of the neuronal cytoskeleton and released into the CSF and the bloodstream with neuronal damage. The concentration of pNf-H in CSF of ALS patients is already significantly increased in the early disease stage. Moreover, the concentration of pNf-H correlates with the degree or degeneration of motoneurons. Several studies suggest that the pNf-H values in CSF and serum correlate. The measurement of pNf-H is therefore suitable for diagnosis, differential diagnosis and prognosis in ALS. It is currently discussed to include this marker in ALS routine diagnostics.

  • Highly specific Neurofilament heavy (pNf-H) ELISAs for CSF, serum and Plasma
  • Only available immunoassays for in vitro diagnostic use
  • Fastest pNf-H ELISAs: Results in up to 2:15 hours
  • Most sensitive pNf-H ELISA available
  • Convenient automation solutions
ProductSample typeRegistrationOrder no.
Neurofilament (pNf-H) ELISACSF, serumCEEQ 6561-9601
Neurofilament (pNf-H) high sensitive ELISASerum, plasmaCEEQ 6562-9601