Secretory IgA

Clinical information

Identifying straining stress is an important basis for treating and preventing many diseases. The quantification of biological stress markers presents a safe and efficient possibility to evaluate the effects of stressors, independently of their underlying cause.

Secretory IgA (sIgA) is produced in the mucous membranes and is the most important and at the same time dominating secretory immunoglobulin. The primary function of sIgA is the defence of pathogens and thus the prevention of infections. Since IgA cannot activate the complement system the defence of pathogens takes place without an immune reaction.

Diagnostics

The sIgA titer is a frequently used indicator for determination of the mucosal immune status. At the same time, it is indirectly associated with stress. The stress-induced reduction of sIgA concentration is independent of the subjective perception of stress. It is also not limited to the time when a stressor affects an individual, but persists beyond that. Consequently, the concentration of sIgA can be used as an indicator for prolonged periods of stress.

The sIgA concentration is an indicator for e.g. psycological/physical load situations, susceptibility to infections, impairments or diseases in the oral area, immunological barrier disorders in the intestinal mucosa (e.g. coeliac disease), autoimmune diseases (e.g. Sjögren’s syndrome) or pharmacological intervention.

In conjunction with the determination of secretory alpha amylase and cortisol, the determination of the sIgA concentration allows estimation of the individual physiopathological effect of stress (stress reactivity).

Selected Products

Method
Parameter
Substrate
Species
ELISA
cortisol
determination in saliva
antibody-coated
microplate wells
ELISA
sIgA
determination in saliva
antibody-coated
microplate wells
ELISA
alpha-amylase
determination in saliva
antibody-coated
microplate wells
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