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Chronische Nierenerkrankungen (CKD) sind häufig mit vaskulärer Verkalkung assoziiert, was das Risiko für kardiovaskuläre Erkrankungen bei CKD-Patienten stark erhöht.
Der bekannteste Hemmstoff von Gefäß- und Gewebekalzifizierung ist Matrix-γ-Carboxyglutaminsäure (Gla) enthaltendes Protein, kurz Matrix-Gla-Protein oder MGP. Hierbei handelt es sich um ein kleines Protein, das in den glatten Gefäßmuskeln, Endothel- und Knorpelzellen synthetisiert wird und aufgrund seiner geringen Größe in die Gefäßwand eindringen kann. Aktiviertes MGP ist in der Lage, freies Kalzium lokal zu binden und damit eine Einlagerung in Gefäße und Gewebe zu verhindern. Bei der Aktivierung von MGP durch γ-Carboxylierung fungiert Vitamin K2 als essenzieller Co-Faktor.
Bei einer ungenügenden Vitamin-K2-Versorgung kommt es zu einem Anstieg von inaktivem MGP, auch dephosphoryliertes uncarboxyliertes MGP (dp-ucMGP) genannt. Dp-ucMGP kann Kalkablagerungen in Gefäßen nicht verhindern. Erhöhte dp-ucMGP-Werte gelten daher als Risikomarker für kardiovaskuläre Erkrankungen. Da die Ursache für hohe dp-ucMGP-Konzentrationen im Plasma ungenügende Vitamin-K2-Zufuhr sein kann, wird dp-ucMGP zudem als aussagekräftiger Marker des Vitamin-K2-Status genutzt.
Die dp-ucMGP-Konzentration lässt Rückschlüsse auf die physiologische Beschaffenheit der Gefäße zu und fungiert somit als wichtiger diagnostischer Prädiktor für negative kardiovaskuläre Folgen und Sterblichkeit. Insbesondere bei älteren Menschen, die zu Arteriosklerose neigen, oder CKD-Patienten empfiehlt es sich, den dp-ucMGP-Spiegel regelmäßig zu bestimmen, um das Risiko von Gefäßkomplikationen zu bewerten.
Darüber hinaus liefert die dp-ucMGP-Messung essenzielle Informationen über den Vitamin-K-Status, denn die dp-ucMGP-Konzentration korreliert direkt mit der Verfügbarkeit von Vitamin K im Körper. Klassische Methoden wie die direkte Messung der Vitamin-K-Konzentration im Plasma bieten hingegen nur eine Momentaufnahme und geben wenig Aufschluss über die Vitamin-K-Verteilung im Gewebe.
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Mr R. Kailasnath
CPC Diagnostics Pvt. Ltd.
600018 Chennai, Tamil Nadu
9 & 10, C.P.Ramaswamy Road
IIIrd Floor, Gokul Towers, Alwarpet
India
Telefon: +91 44 24993989
Fax: +91 44 24993357
E-Mail: immuno(at)cpcdiagnostics.in
Web: www.cpcdiagnostics.in
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Avi Lee
Biotest Ltd.
4952706 Petah Tikva
7 Shimshon St.
P.O.B 2638
Israel
Telefon: +972 9 766 74 54
Fax: +972-97667455
E-Mail: biotest(at)biotest.co.il
Web: www.biotest.co.il
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Mr. Ji Hoon-Sohn
EUROIMMUN Japan Co., Ltd
103-0012 Tokyo
1-9-10 Nihonbashi, Horidome-cho
Chuo-ku
Japan
Telefon: +81 (0) 3-6661-2117
Fax: +81 (0) 3-6661-2117
E-Mail: info(at)euroimmun.co.jp
Web: www.euroimmun.co.jphttps://www.euroimmun.de/de/
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Mrs. Lora Kassim
IMED LLP
010000 Nur-Sultan city
st. Kuishi Dina 23/2-180
Kazakhstan
Telefon: 007701-1255581
E-Mail: kasimlora(at)gmail.com
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Prof. B. Damitow
ImmunoPharma International (for allergy diagnostics)
50042 Almaty
Navoi Street 208, Office 420
Kazakhstan
Telefon: 007-701248266
E-Mail: immunopharma77(at)gmail.com
Web: www.immunopharma.info
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Mrs. Lora Kassim
IMED (all diagnostics except allergy)
50000 Almaty
49 Zhambyl Street
Office 30
Kazakhstan
Telefon: 007701-1255581
E-Mail: lab_mdi(at)mail.ru; kasimlora(at)gmail.com
Web: www.mdi.kz
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Mrs Zora Hanzliková
DYNEX LabSolutions s.r.o.
110 00 Praha
Vodickova 791/41
Czech Republic
E-Mail: office(at)dynex.cz
Web: www.dynex.cz
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Mrs Munguntuya
Setunari LLC
14210 Ulaanbaatar
KhD 24, Chagdarjav street, 1st khoroo
Sukhbaatar district
Mongolia
Telefon: +976-70177015
Fax: +976-70177016
E-Mail: munguntuya(at)setunari.com
Web: www.setunari.com
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Mr. Subash Aryal
ELISA HOUSE Pvt. Ltd.
Koteshwor, Kathmandu
137/11, Jadibuti
Nepal
Telefon: +977 01 -5455112/-5010977
Fax: +977 01 5149093
E-Mail: elisahousepvtltd(at)gmail.com
Web: www.elisahouse.com.np
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Seda Medical
744025 Ashgabat
1922 (S.Myradova) str.
bld.3A
Turkmenistan
Telefon: +993 12 415973/74
Fax: +993 12 415975
E-Mail: info(at)sedamedical.com
Web: www.sedamedical.com
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Ms. Natalia Voronenko
TINYTERIA MED LLC.
01133 Kyiv
34 Lesi Ukrainky Blvd
Ukraine
Telefon: +38 044 468-63-64
Fax: +38 044 468-49-86
E-Mail: office(at)tinyteria.com.ua
Web: www.tinyteria.com.ua
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Mr Stephen Harland-Smith
ESL Biosciences (Australia) (2012) Pty
2150 New South Wales
2-4 Giffnock Avenue
PO Box 202 / Macquarie Park Business Hub /North Ryde BC, NSW 1670, Australia Suite 3
Australia
Telefon: +61 2 98937400
Fax: +61-2-988-73744
E-Mail: Stephen(at)eslbioscience.com
Web: www.eslbioscience.com
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Mr Stephen Harland-Smith
ESL Bioscience (New Zealand) Ltd.
1056 Auckland
6 Mitchelson Street, Ellerslie
PO Box 11706 / Ellerslie, Auckland 1542 Suite 2A
New Zealand
Telefon: +64 9 358 5767
Fax: +64-9-358-4937
E-Mail: Stephen(at)eslbioscience.com
Web: www.eslbioscience.com
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Mrs. Sadjia Bradai
Pharma Ethique SARL
Kouba Alger
Résidence J8, Appreval Lot C N° 169
Algeria
Telefon: +213 (0) 23 60 70 33
Mobile: +213 (0) 560 97 00 02
E-Mail: sarl.pharmaethique(at)gmail.com
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Mr. Emanuel Sá Miranda
EUROIMMUN Portugal, Unipessoal Lda.
2740-122 Porto Salvo
Taguspark
Edifício Tecnologia 2.2, 47
Portugal
Telefon: +351 218 750 000
E-Mail: geral(at)euroimmun.pt
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Ms.Gudrun Sahlmüller
EUROIMMUN Dubai Office/ Academy
Dubai
Business Bay/Bay Square Bldg.6 – 205
UAE
Telefon: +971 4 3708938
E-Mail: g.sahlmueller(at)euroimmun.de
Web: www.euroimmun.com
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Mrs. Claudia Ohst
EUROIMMUN South Africa
7441 Table View - Cape Town
5 Winton Close
South Africa
Telefon: +27 21 5577666
Mobile: +27 72 6062320
Fax: +27 21 5577666
E-Mail: c.ohst(at)euroimmun.co.za
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Heba Mekkawy
Gamma Trade Co. For Scientific Services and Consultation, S.A.E.
Cairo
14th El-Fath St., Off Shehab St., El-Mohandessen
P.O. Box: 61/12655
Egypt
Telefon: +2 02 37480997 (6 lines)
Mobile: +2 0122 2223203
E-Mail: Heba.mekkawy(at)gammatrade.com
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Mrs. Oumou
2Iris
Dakar-Fann
BP 15373 Point E rue 16 x 37 No 4325
Senegal
Telefon: +221 33 824 37 37
Fax: +221 33 824 37 37
E-Mail: oumou.faye(at)2iris.co
Web: www.2iris.com
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Eng. Kutaiba H. Alassaf
Technical Medical Corner - TMC
Erbil
Baghdad AL Saadon Str, 60th str.
Iraq
Telefon: +964 060766993
Mobile: +964 7701755733
Fax: +964 60817002
E-Mail: tmc_iraq(at)yahoo.com
Web: www.tmc-iraq.com
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Mr. Belal Jebriel
Agencies Med. Lab. Trading Company Ltd. (Jordan)
11185 Amman, Khalda
Otba Bin Ghazwan Street
Building no. 26 office no.304
Jordan
Telefon: +9626 5548692
Mobile: +9627 88088886
Fax: +9626 5548693
E-Mail: info(at)amt-jo.com
Web: www.amt-jo.com
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Gitiche Chege
Hospital Consumables Kenya Limited
Nairobi
Mumias South Road
GEMUWA House, office no. 23 Buru Buru Shopping Center, P.O. Box 11038-00100
Kenya
Telefon: +254 202067969
E-Mail: info(at)hckl.co.ke
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Dr. Dalal Mohammad Al Shemali
Innomedics Medical company (IMC)
13114 Safat/Kuwait
KIPCO Tower,25 th floor, Khaled Ibn El Waleed St., Shaq
P.O. Box 25363
Kuwait
Telefon: +965 22215622
Fax: +965 22490959
E-Mail: d.alshemali(at)innomedics.net
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Mr. Pierre Ayoub
Ets. F.A. KETTANEH S.A.
1107-2020 Beirut
Riad El-Solh
P.O. Box 11-0242
Lebanon
Telefon: +9611565301
Fax: +9611565302
E-Mail: pierre.ayoub(at)kettaneh.com
Web: www.kettaneh.com
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Mr. Omar Alujali
Modern Sciences Company
Benghazi
opp.to El Jalla Hospital next to Alrazi Med Lab Flor 1 / Flat 1
Libya
Telefon: +218-92-498-3841
Mobile: +218 914342604
E-Mail: omar_mofadil2001(at)yahoo.com
Web: www.msc.com.ly
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MENOUBIA KHECHIMI
BIOMAX MAURITANIE SARL
Nouakchott
ILOT N° 175 IMMEUBLE LALLA MEDICALE 4e ETAGE
BP 2434, SARL
Mauritania
E-Mail: info(at)biomax-mauritanie.com
Web: www.biomax-mauritanie.com
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Mr. Mohamed Chraibi
BIOCORP SARL
20000 Casablanca
27, Rue Abou Hamed El Ghazali
Quartier Lusitania
Morocco
Telefon: +212 22 48 72 16
Fax: +212 522 487994
E-Mail: biocorp(at)biocorp.ma
Web: www.biocorp.net.ma
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Mr Emanuel Sá Miranda
EUROIMMUN Portugal, Unipessoal Lda
2720-507 Amadora
Rua Sacadura Cabral, 9 A/B
Quinta do Borel
Portugal
Telefon: +351 21 4996552
Fax: +351 21 4996559
E-Mail: geral(at)euroimmun.pt
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Yogini P. Modi
Integrated Medical Solutions L.L.C.
Muscat
Al Hamriya Postal Code 131
P.O. Box 1196
Sultanate of Oman
Telefon: +968 247 07547
Fax: +968 247 07537
E-Mail: yogini(at)imsoman.net
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Mr. Khamis Idkadek
ARCOMed.co.Ltd
Jerusalem (Wadi el jouze)
Jerusalem Ramallah Main Street, Al Hammouri Building
P.O.Box 54260, Salah Ideen St.
Israel
Telefon: +972 2 2956576
Fax: +972 2 2951866
E-Mail: arcomed(at)arcomed.ps
Web: www.arcomed.ps
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Dr. Ahmad Nassar
New Concept Pharma Trade
Doha
Office 304, 30th floor, marina twin towers
Tower B, Lusail
Qatar
Fax: 00974-44353044
E-Mail: a.nass(at)ncpharma.net
Web: www.ncpharma.net
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Claude Audiberti
EUROIMMUN France SAS
77600 Bussy Saint Martin
Espace Villa Parc – L’Erable 1, Avenue Marne et Gondoire
France
Telefon: +33 164616666
Fax: +33 164616220
E-Mail: euroimmun(at)euroimmun.fr
Web: http://www.bio-advance.com/
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Mr. Jalal Stouhi
Samir Trading & Marketing CJSC
21421 Jeddah
Hindi Building, Madina Road Kilo 14, 599
P.O.Box 268 Al Khobar 31952
Kingdom of Saudi Arabia
Telefon: +966 8942674
Fax: +966 38948162
E-Mail: jalal.stouhi(at)samirgroup.com
Web: www.samirgroup.com
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Mrs. Claudia Ohst
EUROIMMUN South Africa (Pty) Ltd
7441 Table View - Cape Town
5 Winton Close
South Africa
Telefon: +27 21 557 7666
Mobile: +27 72 606 2320
E-Mail: c.ohst(at)euroimmun.co.za
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Dr. Khalifa Eltayeb Khalafalla
K-BIOanalytica Co. Ltd.
Khartoum
Al -Sayed Abdel Rahman Street / Al Qasr street Junction
Rayan Specialized laboratory Building/ P.O.Box 11656
Sudan
Telefon: +249 155 121731
Fax: +249 183 741165
E-Mail: k_khalafalla(at)bioanalytica-rayan.com
Web: www.bioanalytica-rayan.com
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Ghazi Mseddi
BMS Biologie Medecine Services
3002 Sfax
Route El Mahdia Km 1 Avenue Palestine No 76
Tunisia
E-Mail: bms(at)gnet.tn
Web: www.bms-biologie.com.tn
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Mr. Ngattu Johnnie Mary
Chemmart Uganda Limited
Uganda
Plot 4-6 Bell close Luzira, UPET House
Behind 2nd Total Fuel Station
UGA
Telefon: +256 394 845 267
Mobile: +256 782 480 969
E-Mail: info(at)chemmartug.com
Web: www.chemmartug.com
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Khalid Abdalla Abdelrahim AL Fahim
AL Fahim Health Care Solutions LLC
Dubai
Boulevard Plaza Tower 2, Office 1904
P.O.Box 90666
United Arab Emirates
Telefon: +971 4 2805852
Mobile: +971 505399422
Fax: +971 505399422
E-Mail: info(at)alfahimhealth.com
Web: www.alfahimhealth.com
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Mr Talal Al-Shoewafi
TMA PHARMA
0967 St. Taizz
266 Jamal Abdul Nasir
Republic of Yemen
Telefon: +967 773 222 444
Fax: +967 1475126
E-Mail: Talal(at)TMApharma.com
Web: www.tmapharma.com
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