Calprotectin

Calprotectin

Calprotectin is produced by neutrophil granulocytes and monocytes. In the case of an inflammatory disease of the intestine, granulocytes pass into the intestinal lumen and release calprotectin which is then excreted with the stool. The concentration of calprotectin in stool is therefore an indicator for the severity of an inflammatory process in the intestine. Hence, this non-invasive stool test enables:

  • Differentiation of irritable bowel syndrome (colon irritabile - low calprotectin level) from acute and chronic inflammations of the intestine (e.g. viral or bacterial infections, Crohn’s disease, ulcerative colitis - increased calprotectin level)
  • Monitoring of the disease course and therapy success in patients with chronic inflammatory bowel diseases: With successful treatment, the formerly increased level of calprotectin decreases significantly and increases again in case of a relapse. This behaviour correlates very well with the histological and endoscopic findings. Therefore, investigation of the calprotectin level can help to avoid biopsies or other complicated examinations.
  • Supporting diagnostics in case of suspected of neoplastic changes in the intestine (e.g. intestinal polyps)
ProductOrder number
Calprotectin-ELISAEQ 6831 W